Subverting the adaptive immune resistance mechanism to improve clinical responses to immune checkpoint blockade therapy

Kim, Young J
December 2014
OncoImmunology;Dec2014, Vol. 3 Issue 12, pN.PAG
Academic Journal
The correlation between tumor-infiltrating lymphocyte (TIL)-expression of programmed cell death ligand 1 (PD-L1) and clinical responsiveness to the PD-1 blocking antibody nivolumab implicates adaptive immune evasion mechanisms in cancer. We review our findings that tumor cell PD-L1 expression is induced by interferon γ (IFNγ) producing TILs. We provide a mechanistic rationale for combining IFNγ+T helper type 1 (Th1)-inducing cancer vaccines with PD-1 immune checkpoint blockade.


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