Plasma and Intracellular Antiretroviral Concentrations in HIV-Infected Patients under Short Cycles of Antiretroviral Therapy

Zehnacker, Laura; Abe, Emuri; Mathez, Dominique; Alvarez, Jean-Claude; Leibowitch, Jacques; Azoulay, Stéphane
January 2014
AIDS Research & Treatment;2014, p1
Academic Journal
Study of plasma and intracellular concentrations of atazanavir, lopinavir, nevirapine, and efavirenz was conducted on 48 patients under short cycles of antiretroviral therapy. Intracellular concentrations (IC) were still measurable for all drugs after 85 h or 110 h drug intake despite the absence of drug in plasma for atazanavir and lopinavir. A linear relationship between plasma and intracellular efavirenz was observed. Further studies to fully understand the impact of IC in the intermittent antiviral treatment are required.


Related Articles

  • Impact of Ritonavir, Atazanavir and Their Combination on the CYP3A4 Induction by Efavirenz in Primary Human Hepatocytes. Mugundu, Ganesh M.; Hariparsad, Niresh; Desai, Pankaj B. // Drug Metabolism Letters;Jan2010, Vol. 4 Issue 1, p45 

    Currently used combinations of anti-HIV drugs, known as Highly Active Antiretroviral Therapy (HAART), have considerably reduced the mortality in patients with AIDS. However, HAART medications such as efavirenz (EFV), atazanavir (ATV) and ritonavir (RTV) often cause adverse drug-drug interactions...

  • Morphological and Metabolic Components of Lipodystrophy in Various Nevirapine-Based Highly Active Antiretroviral Therapy (HAART) Regimens. Guaraldi, Giovanni; Zona, Stefano; Orlando, Gabriella; Carli, Federica; Stentarelli, Chiara; Luzi, Kety; Garlassi, Elisa; Menozzi, Marianna; Bagni, Pietro; Adorni, Fulvio // Clinical Drug Investigation;2011, Vol. 31 Issue 11, p759 

    Background: Morphological abnormalities (lipoatrophy and central fat accumulation) and metabolic changes (dyslipidaemia and glucose regulation impairment) have emerged as components of lipodystrophy and as major tolerability issues with long-term use of highly active antiretroviral therapy...

  • HIV-1 RNA May Decline More Slowly in Semen than in Blood following Initiation of Efavirenz-Based Antiretroviral Therapy. Graham, Susan M.; Holte, Sarah E.; Dragavon, Joan A.; Ramko, Kelly M.; Mandaliya, Kishor N.; McClelland, R. Scott; Peshu, Norbert M.; Sanders, Eduard J.; Krieger, John N.; Coombs, Robert W.; Lama, Javier R. // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1 

    Objectives: Antiretroviral therapy (ART) decreases HIV-1 RNA levels in semen and reduces sexual transmission from HIV-1- infected men. Our objective was to study the time course and magnitude of seminal HIV-1 RNA decay after initiation of efavirenz-based ART among 13 antiretroviral-naïve...

  • Atazanavir.  // Reactions Weekly;8/1/2013, Issue 1463, p11 

    The article presents a case study of a woman who developed unconjugated hyperbilirubinaemia while receiving treatment with atazanavir in a combination antiretroviral therapy.

  • Antiretroviral Therapy for HIV: Do Subtypes Matter? Gatell, José M. // Clinical Infectious Diseases;12/1/2011, Vol. 53 Issue 11, p1153 

    The author discusses the need of recommendations and guidelines for highly active antiretroviral therapy for HIV. He mentions a recommendation which suggests the need of evaluating the impact of host characteristics of the infected population on antiretroviral therapy efficacy and viral subtype....

  • Efficacy and Safety of Once-Daily Nevirapine- or Efavirenz-Based Antiretroviral Therapy in HIVAssociated Tuberculosis: A Randomized Clinical Trial. Swaminathan, Soumya; Padmapriyadarsini, Chandrasekaran; Venkatesan, Perumal; Narendran, Gopalan; Kumar, Santhanakrishnan Ramesh; Iliayas, Sheik; Menon, Pradeep A.; Selvaraju, Sriram; Pooranagangadevi, Navaneetha P.; Bhavani, Perumal K.; Ponnuraja, Chinnaiyan; Dilip, Meenalochani; Ramachandran, Ranjani // Clinical Infectious Diseases;10/1/2011, Vol. 53 Issue 7, p716 

    Background. Nevirapine (NVP) can be safely and effectively administered once-daily but has not been assessed in human immunodeficiency virus (HIV)-infected patients with tuberculosis (TB). We studied the safety and efficacy of once-daily NVP, compared with efavirenz (EFV; standard therapy); both...

  • Efavirenz-based combination antiretroviral therapy after peripartum single-dose nevirapine. Bolhaar, M. G.; Karstaedt, A. S. // International Journal of STD & AIDS;Jan2011, Vol. 22 Issue 1, p38 

    Single-dose nevirapine (sdNVP) reduces mother-to-child HIV transmission, but induces NVP resistance and subsequent NVP-based combination antiretroviral therapy (cART) may fail. Some resistance mutations affect NVP more than efavirenz (EFV). We evaluated virological suppression of EFV-based cART...

  • Nevirapine versus efavirenz-based antiretroviral therapy regimens in antiretroviral-naive patients with HIV and tuberculosis infections in India: a pilot study. Sinha, Sanjeev; Raghunandan, Puroshottam; Chandrashekhar, Rahul; Sharma, Surendra K.; Kumar, Sanjiv; Dhooria, Sahajal; Ekka, Meera; Velpandian, Thirumurthy; Ranjan, Sanjay; Ahmad, Hafeez; Samantaray, Jyoti C.; Venkatesh, Srinivasaraghavan; Bhushan Rewari, Bharat; Hussain Khan, Nawaid; Mohan Pandey, Ravindra // BMC Infectious Diseases;2013, Vol. 13 Issue 1, p1 

    Background Administration of rifampicin along with nevirapine reduces the plasma concentration of nevirapine in human immunodeficiency virus positive individuals with concomitant tuberculosis (HIV-TB patients). Nevirapine is a much cheaper drug than its alternative efavirenz, and might be...

  • Outcomes of starting first-line antiretroviral therapy in hepatitis B virus/HIV-coinfected patients in Ghana. Chadwick, D.; Ankcorn, M.; Sarfo, F.; Phillips, R.; Fox, Z.; Garcia, A.; Appiah, L.; Bedu-Addo, G.; Geretti, A. M. // Journal of Antimicrobial Chemotherapy (JAC);Dec2012, Vol. 67 Issue 12, p2939 

    Objectives HIV/hepatitis B virus (HBV) coinfection is common in Ghana, where first-line antiretroviral therapy (ART) comprises lamivudine with zidovudine or stavudine and nevirapine or efavirenz. Little is known about ART outcomes in the context of coinfection. This study evaluated outcomes of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics