TITLE

Assessment of adherence to highly active antiretroviral therapy and associated factors among people living with HIV at Debrebrihan Referral Hospital and Health Center, northeast ethiopia: a cross-sectional study

AUTHOR(S)
Ketema, Abush Kebede; Weret, Zewdu Shewangizaw
PUB. DATE
March 2015
SOURCE
HIV/AIDS - Research & Palliative Care;2015, Vol. 7, p75
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Patient adherence to antiretroviral combination therapy is a critical component to successful treatment outcome. Nonadherence to antiretroviral therapy (ART) is a major challenge to AIDS care, and the risks associated with it are extensive. The intention of this study was to determine prevalence and associated factors with adherence to highly active ART among people living with HIV/AIDS (PLWHA) at the Debrebrihan Referral Hospital and Health Center, Northeast Ethiopia. A cross-sectional study design with systematic random sampling conducted by the use of a structured, pretested self-rating adherence questionnaire was used to conduct the study among 422 respondents from the Debrebrihan Referral Hospital and Health Center. A single population proportion formula at 95% CI with 5% of marginal error at 50% of prevalence of occurrence was used to determine sample size. Adherence was defined as not missing a single ART dose during the 30-day period prior to filling out the self-report. Adherence was measured by self-reports by the patients. These results were then used in binary logistic regression analysis. Covariates were analyzed by bivariate and multivariate logistic regression with SPSS statistical software. The total number of respondents in this study was 422; their median age was 35 years. Among the participants, 95.5% were taking their medication without missing a dose. Factors such as having emotional or practical support positively encouraged ART adherence (adjusted odds ratio 0.16 [95% CI 0.05-0.49]). However, users of traditional, complementary, and alternative medicine (TCAM) (adjusted odds ratio 4.7 [95% CI 1.06-21.22]) had nearly a five times higher risk for ART nonadherence (P<0.05) than those not using TCAM. Adherence to ART among PLWA is imperative and standard. But, there is still a need to boost psychological support and practical support for the clients, and there is also a need to create a more integrative approach with TCAM in order to increase adherence to ART. Strengthening emotional and practical support for PLWHA and integrating TCAM with the proper use of ART are mandatory to enhance ART adherence.
ACCESSION #
102033052

 

Related Articles

  • Penetration and Effectiveness of Antiretroviral Therapy in the Central Nervous System. Letendre, Scott; Ellis, Ronald J.; Best, Brookie; Bhatt, Archana; Marquie-Beck, Jennifer; LeBlanc, Shannon; Rossi, Steven; Capparelli, Edmund; McCutchan, J. Allen // Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry;Jun2009, Vol. 8 Issue 2, p169 

    Combination antiretroviral therapy (ART) has markedly reduced morbidity and mortality among HIV-infected individuals but not the prevalence of HIV-associated neurocognitive disorders (HAND). Several conditions may be responsible for the high prevalence of cognitive impairment, including...

  • Dysregulation of glucose metabolism in HIV patients: epidemiology, mechanisms, and management. Gutierrez, Absalon; Balasubramanyam, Ashok // Endocrine (1355008X);Feb2012, Vol. 41 Issue 1, p1 

    HIV-infected patients on highly active antiretroviral therapy (HAART) have increased prevalence of a number of chronic metabolic disorders of multifactorial but unclear etiology. These include disorders of lipid metabolism with or without lipodystrophy, insulin resistance, and an increased...

  • Does antiretroviral therapy for HIV reduce the risk of developing multiple sclerosis? van der Kop, Mia L. // Journal of Neurology, Neurosurgery & Psychiatry;Jan2015, Vol. 86 Issue 1, p3 

    The article presents a case study that examines the association of HIV and its treatment with antiretroviral therapy (ART) on multiple sclerosis (MS). Topics discussed include use of data of HIV patients between 1999 and 2011 followed up with records of MS, authors of the study showing that the...

  • Triple-combination rilpivirine, emtricitabine, and tenofovir (Complera/Eviplera) in the treatment of HIV infection. Bernardini, Claudia; Maggiolo, Franco // Patient Preference & Adherence;2013, Vol. 7, p531 

    The combination rilpivirine (RPV)/emtricitabine (FTC)/tenofovir (TDF) is a oncedaily, single-tablet regimen (STR) containing one nonnucleoside reverse-transcriptase inhibitor associated with two nucleos(t)ide reverse transcriptase inhibitors. It is approved by regulatory agencies (eg, US Food...

  • NIGELLA SATIVA CONCOCTION INDUCED SUSTAINED SEROREVERSION IN HIV PATIENT. Adekunle Onifade, Abdulfatah; Jewell, Andrew Paul; Adeola Adedeji, Waheed // African Journal of Traditional, Complementary & Alternative Medi;2013, Vol. 10 Issue 5, p332 

    Nigella sativa had been documented to possess many therapeutic functions in medicine but the least expected is sero-reversion in HIV infection which is very rare despite extensive therapy with highly active anti-retroviral therapy (HAART). This case presentation is to highlight the complete...

  • ICAAC 2009: studies confirm the benefits of early initiation of therapy for HIV.  // PharmaWatch: Biotechnology;Nov2009, Vol. 8 Issue 11, p9 

    The article focuses on the benefits of early initiation of highly active antiretroviral therapy in early diagnosed HIV patients. There has been increasing evidence on the benefits of earlier treatment initiation and that the studies presented at the 2009 Interscience Conference on Antimicrobial...

  • The role of backward mutations on the within-host dynamics of HIV-1. Kitayimbwa, John M.; Mugisha, Joseph Y. T.; Saenz, Roberto A. // Journal of Mathematical Biology;Nov2013, Vol. 67 Issue 5, p1111 

    The quality of life for patients infected with human immunodeficiency virus (HIV-1) has been positively impacted by the use of antiretroviral therapy (ART). However, the benefits of ART are usually halted by the emergence of drug resistance. Drug-resistant strains arise from virus mutations, as...

  • Prevalence of Pulmonary Tuberculosis Among HIV Positive Patients Attending Antiretroviral Therapy Clinic. Giri, Purushottam A.; Deshpande, Jayant D.; Phalke, Deepak B. // North American Journal of Medical Sciences;Jun2013, Vol. 5 Issue 6, p367 

    Background: Tuberculosis (TB) is the most common serious opportunistic infection in HIV positive patients and is the manifestation of AIDS in more than 50% of cases in developing countries. TB can occur at any time during the course of HIV infection. Aim: To describe the socio-demographic...

  • Current treatment methods for combination antiretroviral therapy-induced lipoatrophy of the face. Kadouch, J A; van Rozelaar, L; Karim, R B; Hoekzema, R // International Journal of STD & AIDS;Sep2013, Vol. 24 Issue 9, p685 

    Combination antiretroviral therapy (CART) reduces the mortality and morbidity in HIV-infected patients. However, facial lipoatrophy (FLA) is one of the well-known side-effects of this treatment and subsequently imposes major problems for HIV-infected patients. In the last decade, ample...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics