Imatinib for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation

Watanabe, S; Waseda, Y; Kimura, H; Takato, H; Ohata, K; Kondo, Y; Kasahara, K; Nakao, S
September 2015
Bone Marrow Transplantation;Sep2015, Vol. 50 Issue 9, p1250
Academic Journal
The article presents a study which describes two patient conditions following allogeneic hematopoietic stem cell transplantations (allo-SCT) who develop biopsy-proven bronchiolitis obliterans (BO) that responded well with tyrosine kinase inhibitors (TKIs). It implies that developed BO responds poorly to corticosteroids or immunosuppressants. It recommends that new treatment options are urgently needed to inhibit the progression of BO.


Related Articles

  • Cyclosporine and mycophenolate mofetil prophylaxis with fludarabine and melphalan conditioning for unrelated donor transplantation: a prospective study of 22 patients with hematologic malignancies. Rodriguez, R.; Parker, P.; Nademanee, A.; Smith, D.; O'Donnell, M. R.; Stein, A.; Snyder, D. S.; Fung, H. C.; Krishnan, A. Y.; Popplewell, L.; Cohen, S.; Somlo, G.; Angelopoulou, M.; Al-Kadhimi, Z.; Falk, P. M.; Spielberger, R.; Kogut, N.; Sahebi, F.; Senitzer, D.; Slovak, M. // Bone Marrow Transplantation;Jun2004, Vol. 33 Issue 11, p1123 

    In an attempt to decrease toxicity in high-risk patients undergoing unrelated donor hematopoietic stem cell transplantation (URD HSCT), we tested a combination of cyclosporine (CSP) and mycophenolate mofetil (MMF) as graft-versus-host disease (GVHD) prophylaxis with the reduced-intensity...

  • Lower leukemia relapse in pediatric patients with pulmonary cytolytic thrombi following allogeneic transplant. Smith, A. R.; Gulbahce, E.; Burke, M. J.; Cao, Q.; MacMillan, M. L.; Tolar, J.; Orchard, P. J.; Blazar, B. R.; Baker, K. S.; Wagner, J. E.; Verneris, M. R. // Bone Marrow Transplantation;Mar2011, Vol. 46 Issue 3, p368 

    Pulmonary cytolytic thrombi (PCT) is an uncommon complication after hematopoietic cell transplantation. Although the pathogenesis is unknown, patients typically respond to systemic corticosteroid treatment. Considering corticosteroids may impair GVL reactions, we reviewed the records of 324...

  • Thrombotic Microangiopathy in Haematopoietic Stem Cell Transplantation: Diagnosis and Treatment. Choi, Cecilia M.; Schmaier, Alvin H.; Snell, Michael R.; Lazarus, Hillard M. // Drugs;2009, Vol. 69 Issue 2, p183 

    Each year in the US, more than 10 000 patients benefit from allogeneic haematopoietic stem cell transplantation (HSCT), a modality that offers an excellent chance of eradicating malignancy but confers a higher risk of treatment-related mortality. An uncommon but devastating consequence of HSCT...

  • Administration of short-term immunosuppressive agents after DLI reduces the incidence of DLI-associated acute GVHD without influencing the GVL effect. Huang, X.-J.; Wang, Y.; Liu, D.-H.; Xu, L.-P.; Liu, K.-Y.; Chen, H.; Chen, Y.-H.; Han, W.; Shi, H.-X. // Bone Marrow Transplantation;Sep2009, Vol. 44 Issue 5, p309 

    Donor lymphocyte infusion (DLI) exerts a GVL effect, but its use is limited by a high incidence of GVHD. We retrospectively evaluated the efficacy of administering short-term immunosuppressive agents for prophylaxis against DLI-associated acute GVHD, and its influence on the GVL effect. Seventy...

  • Successful unrelated umbilical cord blood transplantation in children with Shwachman-Diamond syndrome. Vibhakar, R.; Radhi, M.; Rumelhart, S.; Tatman, D.; Goldman, F. // Bone Marrow Transplantation;Nov2005, Vol. 36 Issue 10, p855 

    Summary:Shwachman-Diamond syndrome (SDS) is an autosomal recessive disorder characterized by pancreatic insufficiency and variable degrees of neutropenia. SDS patients are at risk of developing myelodysplasia, aplastic anemia, and leukemic transformation. The role and timing of allogeneic...

  • Bronchiolitis Obliterans After Allogeneic Hematopoietic Stem Cell Transplantation. Williams, Kirsten M.; Chien, Jason W.; Gladwin, Mark T.; Pavletic, Steven Z. // JAMA: Journal of the American Medical Association;7/15/2009, Vol. 302 Issue 3, p306 

    The article offers clinical information on bronchiolitis obliterans syndrome following allogeneic hematopoietic stem cell transplantation (HSCT). Bronchiolitis obliterans syndrome is a progressive and insidious lung disease that occurs in a subset of patients who undergo lung transplantation and...

  • Tolerance and Chimerism after Renal and Hematopoietic-Cell Transplantation. Scandling, John D.; Busque, Stephan; Dejbakhsh-Jones, Sussan; Benike, Claudia; Millan, Maria T.; Shizuru, Judith A.; Hoppe, Richard T.; Lowsky, Robert; Engleman, Edgar G.; Strober, Samuel // New England Journal of Medicine;1/24/2008, Vol. 358 Issue 4, p362 

    We describe a recipient of combined kidney and hematopoietic-cell transplants from an HLA-matched donor. A post-transplantation conditioning regimen of total lymphoid irradiation and antithymocyte globulin allowed engraftment of the donor's hematopoietic cells. The patient had persistent mixed...

  • Lung Transplantation for Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation. Yu Ri Kim; Seok Jin Haam; Yoon Ghil Park; Beom Jin Lim; Yoo Mi Park; Hyo Chae Paik // Yonsei Medical Journal;Sep2012, Vol. 53 Issue 5, p1054 

    Bronchiolitis obliterans (BO) is a late onset complication of allogeneic hematopoietic stem cell transplantation (HSCT), and treatment outcome is dismal if it does not respond to immunosuppressive therapy. A 21-year-old male diagnosed with acute myeloid leukemia received an allogeneic HSCT from...

  • Automated washing of autologous hematopoietic stem cell grafts after thawing does not impair engraftment. Calmels, B; Drezet, A; Huynh, C; Autret, A; Stoppa, A-M; Bouabdallah, R; Coso, D; Malenfant, C; Lemarié, C; Chabannon, C // Bone Marrow Transplantation;Aug2014, Vol. 49 Issue 8, p1127 

    A letter to the editor is presented which discusses the study showing the negative effect of automated washing of autologous hematopoietic stem cell grafts after thawing in engraftment.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics