TITLE

Regeneration of Inner Ear Cells from Stem Cell Precursors— A Future Concept of Hearing Rehabilitation?

AUTHOR(S)
Dazert, S.; Aletsee, C.; Brors, D.; Sudhoff, H.; Ryan, A.F.; Müller, A.M.
PUB. DATE
September 2003
SOURCE
DNA & Cell Biology;Sep2003, Vol. 22 Issue 9, p565
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The use of stem cells offers new and powerful strategies for future tissue development and engineering. Common features of stem cells are both their capacity for self-renewal and the ability to differentiate into mature effector cells. Since the establishment of embryonic stem cells from early human embryos, research on and clinical application of human ES cells belong to the most controversial topics in our society. Great hopes are based upon the remarkable observation that human ES cells can be greatly expanded in vitro, and that they can differentiate into various clinically important cell types. Recent advances in the cloning of mammals by nuclear transplantation provide new concepts for autologous replacement of damaged and degenerated tissues. In contrast, somatic stem cells of the adult organism were considered to be more restricted in their developmental potential. However, recent investigations suggest that somatic stem cells may have a wider differentiation potential than previously thought. In otology, initial experiments have revealed neural stem cell survival in cochlear cell cultures and under neurotrophin influence, neural stem cells seemed to develop into a neuronal phenotype. Further studies have to be carried out to investigate the full potential of stem cells as well as the molecular mechanisms that are involved in regulating cellular identity and plasticity. Clinically, advances in stem cell biology may provide a permanent source of replacement cells for treating human diseases and could open the development of new concepts for cell and tissue regeneration for a causal treatment of chronic degenerative diseases.
ACCESSION #
10991637

 

Related Articles

  • Tissue Engineering in Otorhinolaryngology. Bücheler, M.; Haisch, A. // DNA & Cell Biology;Sep2003, Vol. 22 Issue 9, p549 

    Tissue engineering is a field of research with interdisciplinary cooperation between clinicians, cell biologists, and materials research scientists. Many medical specialties apply tissue engineering techniques for the development of artificial replacement tissue. Stages of development extend...

  • Estrategias para la regeneración de tejidos: células, inductores bioquímicos, bionanomateriales y bioconstrucciones. Alcances clínicoquirúrgicos. Valdespino-Gómez, Víctor Manuel; Valdespino-Castillo, Patricia Margarita; Valdespino-Castillo, Víctor Edmundo // Cirugia y Cirujanos;sep/oct2014, Vol. 82 Issue 5, p578 

    Regenerative medicine is a medical multidisciplinary area with the aim of morphologic and functional restoration of tissues or organs in order to re-establish normal function. The main bases of regenerative medicine are the use of autologous stem or progenitor cells and the ex vivo construction...

  • Stem cell therapy - Hype or hope? A review. Nadig, Roopa R. // Journal of Conservative Dentistry;Oct/Nov2009, Vol. 12 Issue 4, p131 

    While the regeneration of a lost tissue is known to mankind for several years, it is only in the recent past that research on regenerative medicine/dentistry has gained momentum and eluded the dramatic yet scientific advancements in the field of molecular biology. The growing understanding of...

  • Regeneration of the limb: opinions on the reality. See, Eugene; Kulkarni, Mangesh; Pandit, Abhay // Journal of Materials Science: Materials in Medicine;Nov2013, Vol. 24 Issue 11, p2627 

    Whenever the topic of re-growing human limbs is posed for discussion, it is often argued that 'if a newt can do it, then so can we'. This notion, albeit promising, is somewhat like watching a science-fiction film; the individual components are currently available but we are far from realizing...

  • Q&A: What is regeneration, and why look to planarians for answers? Alvarado, Alejandro Snchez // BMC Biology;2012, Vol. 10 Issue 1, p88 

    No abstract available.

  • Tissue Engineering Technique Yields Potential Biological Substitute for Dental Implants.  // Clinical Dentistry (0974-3979);Sep2015, Vol. 9 Issue 9, p34 

    The article discusses a cost-effective tissue regeneration technique unveiled by a professor at the Columbia University Medical Center Dr. Jeremy Mao that will help in regenerating a new tooth with the help of the body's stem cells.

  • How stem cells can save your life. Chengappa, Raj // India Today;1/25/2010, p1 

    The article discusses the use of stem cells in India. Described as the storehouse which make up the bones, tissues and organs of the human body, stem cells have the ability to cure diseases such as dilated cardiomyopathy, regenerate tissues and grow new skin. The All India Institute of Medical...

  • Material witness: Shaping fate. Ball, Philip // Nature Materials;Mar2009, Vol. 8 Issue 3, p166 

    The article discusses the promise of stem cell therapies for tissue regeneration. The therapeutic potential of stem cell hinges on the approximation that stem cells can become any other cell type. The author believes that there can be another determinant of stem cell fate. Stem cell may be...

  • New Stem Cell Therapy Shows Promise.  // USA Today Magazine;Feb2013, Vol. 141 Issue 2813, p14 

    The article describes the cell therapy developed by Eduardo Marbán from the Heart Institute in Los Angeles, California which promises to regenerate the injured human heart by growing specialized stem cells.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics