Adherence to anti-retroviral therapy & factors associated with it: a community based cross-sectional study from West Bengal, India

Pahari, Sobha; Roy, Sitesh; Mandal, Alpana; Kuila, Shymal; Panda, Samiran
September 2015
Indian Journal of Medical Research;Sep2015, Vol. 142 Issue 3, p301
Academic Journal
Background & objectives: Failure to adhere to anti-retroviral therapy (ART) can lead to a range of unfavourable consequences impacting upon people living with HIV (PLH) and society. It is, therefore, paramount that ART adherence is measured in a reliable manner and factors associated with adherence are identified. Lack of such data from West Bengal necessitated undertaking the current study. Methods: Participants were included during August-October, 2011 from three Drop-In-Centres (DICs) from the three districts of West Bengal, India. ART-adherence was calculated by using formula based on pill-count and records collected from ART-card in possession of each of the 128 consenting adult PLH. Information on self-reported adherence, socio-demography, and adherence influencing issues was also collected through interviewer-administered questionnaire. Results: Of the 128 PLH, 99 (77%) and 93 (73%) PLH had ≥90 per cent and ≥95 per cent adherence, respectively to ART. Conversely, subjective reporting captured much higher proportion of PLH as 'well adherent'; a finding having implications for ongoing ART programme. Factors, independently associated with poor adherence (<90%), were '7th to 12th month period of ART intake' (adjusted OR=9.5; 90% CI 1.9 - 47.3; p=0.02) and 'non-disclosure of HIV status to family members' (adjusted OR=4; 90% CI 1.3 - 13; p=0.05. Results at 95 per cent adherence cut-off were similar. Interpretation & conclusions: Enabling environment, which would encourage people to disclose their HIV status and in turn seek adherence partners from families and beyond and ongoing adherencecounselling appear to be important issues in the programme. Relevance of these study findings in wider context is conceivable.


Related Articles

  • Alcohol use, antiretroviral therapy adherence, and preferences regarding an alcohol-focused adherence intervention in patients with human immunodeficiency virus. Kekwaletswe, Connie T.; Morojele, Neo K. // Patient Preference & Adherence;2014, Vol. 8, p401 

    Background: The primary objectives of this study were to determine the association between alcohol and antiretroviral therapy (ART) adherence and the perceived appropriateness and acceptability of elements of an adherence counseling program with a focus on alcohol-related ART nonadherence among...

  • Motivational interviewing and concordance with antiretroviral therapy. Brown, Michelle; Bennett, Clare // Nursing Standard;12/1/2010, Vol. 25 Issue 13, p51 

    Concordance with therapy is essential in maintaining quality of life for individuals who have human immunodeficiency virus. This article examines the use of motivational interviewing in assisting people to increase their concordance with antiretroviral therapy. It investigates the evidence base...

  • High adherence to antiretrovirals in rural Uganda.  // PharmacoEconomics & Outcomes News;8/26/2006, Issue 510, p6 

    The article presents the results of a study regarding high adherence to antiretrovirals in rural Uganda. The study revealed that a home-based care programme can achieve good adherence and response to antiretroviral therapy in African patients with HIV infection. The quarterly mean pill count...

  • Adherence to anti-retroviral therapy among HIV patients in Bangalore, India. Cauldbeck, Mary B.; O'Connor, Catherine; O'Connor, Mortimer B.; Saunders, Jean A.; Rao, Bhimasena; Mallesh, V. G.; Praveen Kumar, Nagendrappa Kotehalappa; Mamtha, Gurushanthappa; McGoldrick, Claire; Laing, Robert B. S.; Satish, Kadappa Shivappa // AIDS Research & Therapy;2009, Vol. 6, Special section p1 

    Introduction: Human Immunodeficiency Virus (HIV) has an estimated prevalence of 0.9% in India (5.2 million). Anti-retroviral drugs (ARV) are the treatments of choice and non-adherence is an important factor in treatment failure and development of resistance, as well as being a powerful predictor...

  • Adherence to Highly Active Antiretroviral Therapy in HIV-Infected Inmates. Inés, Sandra M.; Moralejo, Leticia; Marcos, Miguel; Fuertes, Aurelio; Luna, Guillermo // Current HIV Research;Mar2008, Vol. 6 Issue 2, p164 

    Adherence to highly active antiretroviral therapy (HAART) has been scarcely studied in correctional settings. Our study aims to evaluate the relationship between adherence and virological outcome and to determine factors related to adherence in correctional settings. A cross-sectional...

  • Competing priorities: ART adherence presents the health care community with a spectrum of challenges. Volansky, Rob // Infectious Disease News;Jan2010, Vol. 23 Issue 1, p1 

    The article focuses on the views of medical experts about the challenges posed by the study of antiretrovial therapy (ART) among patients with HIV/AIDS.

  • Poor antiretroviral taste leads to non-compliance in paediatrics.  // PharmacoEconomics & Outcomes News;10/29/2011, Issue 640, p8 

    The article reports on a Canadian study which shows that physicians' who do not consider the unpalatability of antiretroviral drugs such as Ritonavir in their antiretroviral therapy prescriptions has led to non-adherence by a third of patients infected by human immunodeficiency virus (HIV).

  • THE USING OF ARV PATTERN TO PATIENTS ON HIV/AIDS IN UPIPI Dr. SOETOMO HOSPITAL, SURABAYA, JANUARY - JUNE 2011. Sari, Retno Juwita; Srihartini, Indah; Triyono, Erwin Astha // Folia Medica Indonesiana;2013, Vol. 49 Issue 3, p182 

    This study aims to determine how patterns of use of antiretroviral agents in HIV/AIDS patients in UPIPI RSUD Dr. Soetomo during January-June 2011. The method of the study conducted retrosprektif observational data and analyzed using descriptive. The results showed than 202 patients, ARV regimens...

  • Baseline adherence, socio-demographic, clinical, immunological, virological and anthropometric characteristics of 242 HIV positive patients on ART in Malaysia. Abiola, Abdulrahman Surajudeen; Rampal, Lekhraj; Othman, Norlijah; Ibrahim, Faisal; @Shahar, Hayati Kadir; Radhakrishnan, Anuradha P. // Malaysian Journal of Medicine & Health Sciences;Jun2015, Vol. 11 Issue 2, p45 

    Adherence to antiretroviral therapy (ART) prevents disease progression, and the emergence of resistant mutations. It also reduces morbidity, and the necessity for more frequent, complicated regimens which are also relatively more expensive. Minimum adherence levels of 95% are required for...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics