What is the best method of diagnosing onychomycosis?

Rea, Cathy; Greenawald, Mark H.
December 2003
Journal of Family Practice;Dec2003, Vol. 52 Issue 12, p929
Academic Journal
This study indicated that nail plate biopsy followed by periodic acid-Schiff staining is the most accurate method for diagnosing onychomycosis. The positive predictive value (PV+) of periodic acid-Schiff staining was equal to both potassium hydroxide (KOH) preparation and fungal culture, with a greater negative predictive value (PV-) due to superior sensitivity. However, availability of periodic acid-Schiff staining may vary geographically, and the cost of the diagnostic tests is not addressed in this study. Thus, it makes clinical sense to start with the most accessible test, using periodic acid-Schiff staining if other methods are negative and clinical suspicion is high.


Related Articles

  • Neoplastic and nonneoplastic ovarian masses: Diagnosis on cytology. KHAN, NAZOORA; AFROZ, NISHAT; AQIL, BARINA; KHAN, TAMKIN; AHMAD, IBNE // Journal of Cytology;Oct-Dec2009, Vol. 26 Issue 4, p129 

    Objective: To evaluate the role of fine needle aspiration cytology (FNAC) in the distinction between neoplastic and nonneoplastic ovarian masses.Materials and Methods: One hundred and twenty patients with ovarian masses were studied. After detailed history and clinical examination, ultrasound...

  • Clinico-Pathological Co-relation in Leprosy. Mehta, Bhavesh; Desai, N. J.; Tutor, Shital Khar // Internet Journal of Dermatology;2012, Vol. 9 Issue 1, p1 

    Introduction: Leprosy is an important communicable disease caused by M. leprae, and one of the major health problems of developing countries like India. Most of the time, clinical judgment is adequate for diagnosis. But in some, especially early and borderline cases of leprosy histopathology,...

  • Treating Onychomycosis. Rodgers, Phillip; Bassler, Mary // American Family Physician;2/15/2001, Vol. 63 Issue 4, p663 

    Onychomycosis accounts for one third of fungal skin infections. Because only about one half of nail dystrophies are caused by fungus, the diagnosis should be confirmed by potassium hydroxide preparation, culture or histology before treatment is started. Newer, more effective antifungal agents...

  • Onikomikoz tanısında kullanılan beÅŸ farklı yöntemin etkinlik ve maliyet karşılaÅŸtırması. Erkan, Faruk; Doğruk Kaçar, Seval; Özuğuz, Pınar; Aşık, Gülşah; Tokyol, Çiğdem; Karaca, Şemsettin // Archives of the Turkish Dermatology & Venerology / Turkderm;Mar2014, Vol. 48 Issue 1, p21 

    Background and Design: We aimed to compare the diagnostic value and cost-effectiveness of the diagnostic tests in patients with clinical findings suggesting onychomycosis as well as to assess the factors that affect these diagnostic tests. Material and Method: We evaluated the efficiency and...

  • HMB-45 Staining Useful in Identifying melanoma. Bowser Melanoma in Frozen Sections, Andrew // Dermatology Times;Aug98, Vol. 19 Issue 8, p8 

    Discusses the use of HMB-45 stain in identifying the presence or absence of melanoma in frozen sections of tissues taken during Moh's surgery. Positive result for melanoma; Problem encountered during the interpretation of frozen sections; Disadvantage of HMB-45 stain as a specific melanoma marker.

  • Diagnostic dilemma in female genital tuberculosis-staining techniques revisited. Kashyap, Bineeta; Srivastava, Namita; Graduate, Post; Kaur, Iqbal R.; Jhamb, Rajat; Singh, Deepak K. // Iranian Journal of Reproductive Medicine;Jul2013, Vol. 11 Issue 7, p545 

    Background: Tuberculosis (TB) is an increasing public health concern worldwide. On a global scale it has a devastating impact in developing nations. Genital TB, an extrapulmonary form, is not uncommon particularly in areas where pulmonary TB is prevalent. Genital TB may be asymptomatic or may...

  • "Diskret" Papüler Müsinoz: Liken Miksödematozun Nadir Bir Subtipi. Akış, Havva Kaya; Eskioğlu, Fatma; Öztürk, Evrim // Archives of the Turkish Dermatology & Venerology / Turkderm;2011, Vol. 45 Issue 2, p104 

    Lichen myxoedematosus (synonym, papular mucinosis) is an uncommon, chronic, idiopathic disorder characterized by lichenoid papules, nodules and/or plaques due to dermal mucin deposition and a variable degree of fibrosis in the absence of thyroid dysfunction. Actually, lichen myxoedematosus...

  • S-100 immunostaining in the Distinction of Borderline Tuberculoid Leprosy from other Cutaneous Granulomas. Tirumalae, Rajalakshmi; Stany, Anto Ignat; Shanubhogue, Sharan; Yeliur, Inchara K. // Indian Journal of Dermatology;Jul/Aug2014, Vol. 59 Issue 4, p1 

    Background: Histopathologic diagnosis of borderline tuberculoid leprosy (BTL) is fraught with hurdles. It overlaps with other granulomas and documenting nerve involvement is the key to correct diagnosis. This is difficult on H and E sections alone. S-100 immunostaining may help in this regard....

  • Finger necrosis due to cryoglobulinemic vasculitis in association with membranous nephropathy. Porres-Aguilar, Mateo; Rodriguez-Castro, Carlos E.; Osvaldo, Padilla; Saifuddin, Fátima; Siddiqui, Tariq; Fan, Jerry; Mukherjee, Debabrata; Pema, Kanchan; Abbas, Aamer // Baylor University Medical Center Proceedings;Jan2015, Vol. 28 Issue 1, p72 

    Cryoglobulinemic vasculitis is a small vessel vasculitis that has been associated with chronic infections and autoimmune, lymphoproliferative, and neoplastic disorders. When no significant etiological factors are identified, it is called essential mixed cryoglobulinemia. A detailed and thorough...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics