TITLE

Results of an Autologous Noncryopreserved, Unmanipulated Peripheral Blood Hematopoietic Stem Cell Transplant Program: A Single-Institution, 10-Year Experience

AUTHOR(S)
Ruiz-Argüelles, Guillermo J.; Gómez-Rangel, David; Ruiz-Delgado, Guillermo J.; Ruiz-Argüelles, Alejandro; Pérez-Romano, Beatriz; Rivadeneyra, Liliana
PUB. DATE
December 2003
SOURCE
Acta Haematologica;Dec2003, Vol. 110 Issue 4, p179
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Methods to simplify the stem cell transplantation procedures are needed mainly in developing countries. We have previously shown that unprocessed leukapheresis material is useful to restore hematopoiesis after high-dose chemotherapy. Methods: Over a 10-year period in a private practice setting, we prospectively performed autotransplants using noncryopreserved and unmanipulated peripheral blood stem cells mobilized from the bone marrow to the peripheral blood by means of filgrastim and using a single-day conditioning regimen with high dose (200 mg/m[sup 2] ) melphalan. Results: Forty-six individuals were given 50 autografts. The median age of the patients was 33 years (range 8–69). Twenty-two patients with acute leukemia (13 with myeloblastic and 9 with lymphoblastic leukemia), 4 with chronic myelogenous leukemia, 6 with multiple myeloma, 7 with Hodgkin’s disease, 3 with non-Hodgkin’s lymphoma and 4 with metastatic breast carcinoma were included. The median time to achieve >0.5 × 10[sup 9] /l granulocytes was 14 days (range 0–86), whereas the median time to achieve >20 × 10[sup 9] /l platelets was 25 days (range 0–102). The 3,300-day posttransplant survival was 63%, the median posttransplant overall survival was over 3,300 days, the 3,300-day disease-free survival was 50% and the transplant-related mortality was 2%. The procedure was performed entirely on an outpatient basis in the case of 48 autografts (96%). The approximate cost of each graft was 7,500 USD. Conclusion: This simplified method to autograft patients, avoiding in-hospital stays, purging procedures and cryopreservation of the cells, is feasible and results in a substantial decrease in the cost of the autologous hematopoietic stem cell transplantation methods. Copyright © 2003 S. Karger AG, Basel
ACCESSION #
11762777

 

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