TITLE

Fibroblast-like cells as an effective feeder for the cultivation and derivation of new lines of human induced pluripotent stem cells

AUTHOR(S)
Novosadova, E.; Manuilova, E.; Arsenyeva, E.; Grivennikov, I.; Myasoedov, N.
PUB. DATE
September 2016
SOURCE
Doklady Biochemistry & Biophysics;Sep2016, Vol. 470 Issue 1, p353
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Induced pluripotent stem cells (iPSCs) can be a highly informative model of hereditary and sporadic human diseases. In the future, such cells can be used in substitution and regenerative therapy of a wide range of diseases and for the treatment of injuries and burns. The ability of iPSCs derived from patients with Parkinson's disease to differentiate into fibroblast-like cells (derivatives) was studied. It was found that these cells can serve as an effective feeder layer not only to maintain the pluripotency of allogenic and autologous iPSCs but also to derive new iPSC lines.
ACCESSION #
119283041

 

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