Assessing Sex Differences in the Risk of Cardiovascular Disease and Mortality per Increment in Systolic Blood Pressure: A Systematic Review and Meta-Analysis of Follow-Up Studies in the United States

Wei, Yu-Chung; George, Nysia I.; Chang, Ching-Wei; Hicks, Karen A.
January 2017
PLoS ONE;1/25/2017, Vol. 12 Issue 1, p1
Academic Journal
In the United States (US), cardiovascular (CV) disease accounts for nearly 20% of national health care expenses. Since costs are expected to increase with the aging population, informative research is necessary to address the growing burden of CV disease and sex-related differences in diagnosis, treatment, and outcomes. Hypertension is a major risk factor for CV disease and mortality. To evaluate whether there are sex-related differences in the effect of systolic blood pressure (SBP) on the risk of CV disease and mortality, we performed a systematic review and meta-analysis. We conducted a comprehensive search using PubMed and Google Scholar to identify US-based studies published prior to 31 December, 2015. We identified eight publications for CV disease risk, which provided 9 female and 8 male effect size (ES) observations. We also identified twelve publications for CV mortality, which provided 10 female and 18 male ES estimates. Our meta-analysis estimated that the pooled ES for increased risk of CV disease per 10 mmHg increment in SBP was 25% for women (95% Confidence Interval (CI): 1.18, 1.32) and 15% for men (95% CI: 1.11, 1.19). The pooled increase in CV mortality per 10 mm Hg SBP increment was similar for both women and men (Women: 1.16; 95% CI: 1.10, 1.23; Men: 1.17; 95% CI: 1.12, 1.22). After adjusting for age and baseline SBP, the results demonstrated that the risk of CV disease per 10 mm Hg SBP increment for women was 1.1-fold higher than men (P<0.01; 95% CI: 1.04, 1.17). Heterogeneity was moderate but significant. There was no significant sex difference in CV mortality.


Related Articles

  • Lipid profiles and ovarian reserve status: a longitudinal study. Tehrani, Fahimeh Ramezani; Erfani, Hadi; Cheraghi, Leila; Tohidi, Maryam; Azizi, Fereidoun // Human Reproduction;Nov2014, Vol. 29 Issue 11, p2522 

    STUDY QUESTION Is there any association between ovarian reserve status and lipid profile changes? SUMMARY ANSWER Women with lower ovarian reserve might be susceptible to higher cardiovascular risks, especially lipid disturbances, even during their reproductive life span. WHAT IS KNOWN ALREADY...

  • Association between Adiponectin Concentrations and Cardiovascular Disease in Diabetic Patients: A Systematic Review and Meta-Analysis. Wu, Zhenjie; Cheng, Yunjiu; Aung, Lynn Htet Htet; Li, Bixun // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    Background: This systematic review and meta-analysis of prospective studies evaluates the association between adiponectin concentrations and risk of cardiovascular disease (CVD) in individuals with diabetes mellitus (DM). Methods: PubMed and Embase were searched for prospective studies on the...

  • Heterogeneity of Prognostic Studies of 24-Hour Blood Pressure Variability: Systematic Review and Meta-Analysis. Taylor, Kathryn S.; Heneghan, Carl J.; Stevens, Richard J.; Adams, Emily C.; Nunan, David; Ward, Alison // PLoS ONE;May2015, Vol. 10 Issue 5, p1 

    In addition to mean blood pressure, blood pressure variability is hypothesized to have important prognostic value in evaluating cardiovascular risk. We aimed to assess the prognostic value of blood pressure variability within 24 hours. Using MEDLINE, EMBASE and Cochrane Library to April 2013, we...

  • War-related stress exposure and mortality: a meta-analysis. Roelfs, David; Shor, Eran; Davidson, Karina; Schwartz, Joseph // International Journal of Epidemiology;Dec2010, Vol. 39 Issue 6, p1499 

    Background: Domestic and international wars continue to be pervasive in the 21st century. This study summarizes the effects of war-related stress on all-cause mortality using meta-analyses and meta-regressions.Methods: A keyword search was performed, supplemented by...

  • Program-related factors are associated with adherence to group exercise interventions for the prevention of falls: a systematic review. McPhate, Lucy; Simek, Emily M.; Haines, Terry P. // Journal of Physiotherapy (Elsevier);Jun2013, Vol. 59 Issue 2, p81 

    Questions: What factors are associated with adherence of older adults to group exercise interventions for the prevention of falls? What is the relationship between adherence and the falls prevention efficacy of the intervention? Design: Systematic review with meta-analysis of randomised trials....

  • Systematic review of studies on telemonitoring of patients with congestive heart failure: a meta-analysis. Clarke, Malcolm; Shah, Anila; Sharma, Urvashi // Journal of Telemedicine & Telecare;Jan2011, Vol. 17 Issue 1, p7 

    We conducted a systematic review of large, well-conducted randomized trials designed to evaluate the effectiveness of telemonitoring on patients with congestive heart failure (CHF). Two people reviewed 125 articles independently and selected 13 articles for final review. These studies concerned...

  • Systematic review and meta-analyses of risk factors for childhood overweight identifiable during infancy. Weng, Stephen Franklin; Redsell, Sarah A.; Swift, Judy A.; Min Yang; Glazebrook, Cristine P. // Archives of Disease in Childhood;Dec2012, Vol. 97 Issue 12, p1019 

    Objective To determine risk factors for childhood overweight that can be identified during the first year of life to facilitate early identification and targeted intervention. Design Systematic review and meta-analysis. Search strategy Electronic database search of MEDLINE, EMBASE, PubMed and...

  • Systematic Review and Meta-Analysis of the Impact of Carer Stress on Subsequent Institutionalisation of Community-Dwelling Older People. Donnelly, Nora-Ann; Hickey, Anne; Burns, Annette; Murphy, Paul; Doyle, Frank // PLoS ONE;Jun2015, Vol. 10 Issue 6, p1 

    Background: In the caregiving literature there is a common assertion that a higher level of carer stress is a critical determinant of premature ending of homecare. However, this contention has not been systematically assessed. We therefore systematically reviewed and meta-analysed the...

  • Links between discrimination and cardiovascular health among socially stigmatized groups: A systematic review. Panza, Gregory A.; Puhl, Rebecca M.; Taylor, Beth A.; Zaleski, Amanda L.; Livingston, Jill; Pescatello, Linda S. // PLoS ONE;6/10/2019, Vol. 14 Issue 6, p1 

    Background: There is a high prevalence of cardiovascular disease across diverse groups in the U.S. population, and increasing research has identified stigma as a potential barrier to cardiovascular disease prevention and treatment. This systematic review examines evidence linking discrimination...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics