TITLE

ESTERIFICATION OF STEROLS DURING DIFFERENTIATION AND CORNIFICATION OF DEVELOPING RAT EPIDERMIS

AUTHOR(S)
Freinkel, Ruth K.; Fiedler-Weiss, Virginia
PUB. DATE
April 1974
SOURCE
Journal of Investigative Dermatology;Apr74, Vol. 62 Issue 4, p458
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The proportion of sterols in esterified form increase during stratification and cornification of the fetal and newborn rat whole skin and epidermis. This change cannot e ascribed either to development of alternative biosynthetic pathways favoring formation of sterol esters or to a commensurate increase in cholesterol-fatty acyl transferase. The activity of the latter enzyme, in fact, decreases from day 17 of gestation to 7 days postpartum. The decline in enzymatic activity is not due to the presence of inhibitors or exhaustion of endogenous substrate but may reflect changing proportions of epidermal cells in progressive stages of maturation. It is concluded that the increase in sterol esters is due to the increased availability of free fatty acids and sterols provided by the degradation of intracellular membranes during cornification.
ACCESSION #
12701701

 

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