TITLE

Regulation effects of melatonin on bone marrow mesenchymal stem cell differentiation

AUTHOR(S)
Wang, Biao; Wen, Hao; Smith, Wanli; Hao, Dingjun; He, Baorong; Kong, Lingbo
PUB. DATE
February 2019
SOURCE
Journal of Cellular Physiology;Feb2019, Vol. 234 Issue 2, p1008
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Melatonin's therapeutic potential has been highly underestimated because its biological functional roles are diverse and relevant mechanisms are complicated. Among the numerous biological activities of melatonin, its regulatory effects on pluripotent mesenchymal stem cells (MSCs), which are found in bone marrow stem cells (BMSCs) and adipose tissue (AD‐MSC), have been recently proposed, which has received increasingly more attention in recent studies. Moreover, receptor‐dependent and receptor‐independent responses to melatonin are identified to occur in these cells by regulating signaling pathways, which drive the commitment and differentiation of MSCs into osteogenic, chondrogenic, or adipogenic lineages. Therefore, the aim of our current review is to summarize the evidence related to the utility of melatonin as a regulatory agent by focusing on its relationship with the differentiation of MSCs. In particular, we aimed to review its roles in promoting osteogenic and chondrogenic differentiation and the relevant signaling cascades involved. Also, the roles that melatonin and, particularly, its receptors play in these processes are highlighted.
ACCESSION #
133118977

 

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