TITLE

IN THE BACKSTAGE OF LACTOFERRIN DERIVED PEPTIDES' ANTIVIRAL ACTIVITY

AUTHOR(S)
Sultana, Camelia; Roşca, Adelina; Grancea, Camelia; Florian, Paula; Lazãr, Cãtãlin; Nichita, Norica; Roşeanu, Anca; RuțÃ, Simona
PUB. DATE
July 2018
SOURCE
Romanian Archives of Microbiology & Immunology;Jul-Sep2018, Vol. 77 Issue 3, p213
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: Lactoferrin (LF) is a transferrin family protein present in blood and in almost all of the exocrine secretions of mammals (milk, saliva, bile, tears, etc.) which exhibits a variety of biological functions, such as influencing iron homeostasis, modulating the immune response, and exerting anti-infectious properties against a broad range of Gram-positive and Gram-negative bacteria and viruses. Objectives: LF and its derivatives can represent effective alternatives or adjuvants to the current antiviral therapies that carry the risk of numerous side effects and resistance emergence. Methods: This review summarizes the data gathered up to date on the antiviral activity of lactoferrin and peptides derived from different domains of this multifaceted molecule. Results: Antiviral effects reported for peptides derived from N-terminal domain (Lactoferricin, Lactoferrampin, LF1-11, HLP1-23, LF-33) and peptides derived from C-terminal domain (corresponding to sequences 506-522, 418-429, 553-563 and 600-632) were analyzed and compared with the properties of the native molecule; the results indicated the capacity of LF and a series of LF-derivates to interfere with the early stages of the life cycle of a wide variety of viruses. Short synthetic peptides have the advantages of a low molecular weight and offer the possibility of in vitro molecular simulation studies that can potentially improve their antiviral activity. Conclusion: The LF-derived peptides could represent promising candidates for prophylaxis or treatment of a broad spectrum of viral infections.
ACCESSION #
135203111

 

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