Building a Human Brain for Research

Bitar, Maina; Barry, Guy
February 2020
Frontiers in Molecular Neuroscience;2/18/2020, Vol. 13, p1
Academic Journal
Graph: Figure 1 Multiple systems are possible for the use of reprogrammed human stem cells in the investigation of human brain development, function, and disease. Through the exploration of self-organizing capabilities of the brain, Lancaster et al. in 2013 established an iPSC-derived, 3D culture system that opened up new opportunities for modeling and exploring human brain development. The future of organoids could lead to the ability to create almost any system of brain connections, both within the brain as "assembloids" (Pasca, [25]), but also within the whole body wherever the brain is connected via the central and peripheral nervous systems.


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