Emtricitabine/Tenofovir Disoproxil Fumarate: A Viewpoint by Daniel Podzamczer

Podzamczer, Daniel
September 2004
Drugs;2004, Vol. 64 Issue 18, p2083
Academic Journal
Emtricitabine/tenofovir disoproxil fumarate combination has many advantages as a highly active antiretroviral therapy (HAART) for HIV infection. Both compounds are potent and well tolerated by patients. The compounds have been proven effective as part of different HAART regimens in clinical trials. Since both drugs are given as a daily single pill, they allow a simple HAART regimen to be administered. Available pharmacokinetic data suggest that the combination is safe. In addition, bioequivalence between the fixed combination and the two separate agents has recently been demonstrated. Large clinical trials are needed to confirm the benefits of the combination. In this setting, the fixed-dose combination will reduce the number of pills needed and improve treatment adherence.


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