TITLE

Poly-L-Lactic Acid

AUTHOR(S)
Perry, Caroline M.
PUB. DATE
May 2004
SOURCE
American Journal of Clinical Dermatology;2004, Vol. 5 Issue 5, p361
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
â–´ Poly-L-lactic acid, a synthetic biodegradable polymer, is available as an injectable intradermal implant for use in the correction and restoration of the signs of facial lipoatrophy in patients with HIV infection. â–´ In a 96-week noncomparative study in HIV-infected patients with severe facial lipoatrophy, 41% of patients treated with intradermal poly-L-lactic acid injections had a total cutaneous thickness of >10mm at the nasogenian fold at week 24. Poly-L-lactic acid was injected into multiple sites of each cheek at baseline and at weeks 2, 4, and 6. â–´ Significant (p < 0.001) increases from baseline in total cutaneous thickness were reported at all evaluation timepoints up to 96 weeks after the start of treatment. â–´ In a randomized, nonblind study, significant (p < 0.001) increases from baseline in dermal thickness were observed at week 24 in HIV-infected patients with facial lipoatrophy who received immediate or deferred (by 12 weeks) treatment with poly-L-lactic acid, administered by injection into multiple intradermal sites every 2 weeks (three injection sessions in total). â–´ Improvements in depression and anxiety scores, patient visual analog scale assessments, and photographic assessments were also reported in patients treated with poly-L-lactic acid in the immediate versus deferred treatment trial. â–´ Poly-L-lactic acid was generally well tolerated. No serious adverse events were reported.
ACCESSION #
15148922

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics