TITLE

Birth Weight and Subsequent Cholesterol Levels: Exploration of the “Fetal Origins” Hypothesis

AUTHOR(S)
Huxley, Rachel; Owen, Christopher G.; Whincup, Peter H.; Cook, Derek G.; Colman, Sam; Collins, Rory
PUB. DATE
December 2004
SOURCE
JAMA: Journal of the American Medical Association;12/8/2004, Vol. 292 Issue 22, p2755
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Context Inverse associations between birth weight and subsequent blood cholesterol levels have been used to support the “fetal origins” hypothesis of the relevance of fetal nutrition to adult disease. Objectives To perform a systematic review of the association between birth weight and total blood cholesterol levels, and to explore the impact of including unpublished results, adjusting for potential confounders. Data Sources and Study Selection Relevant studies published by September 30, 2004, were identified through literature searches using EMBASE and MEDLINE and MeSH heading search strategy (using terms such as birth weight, intrauterine growth retardation, fetal growth retardation and cholesterol, lipoprotein, lipid). Studies that reported qualitative or quantitative estimates of the association between birth weight and total blood cholesterol, or had recorded both measures but not reported on their associations, were included. Data Extraction A total of 79 relevant studies involving a total of 74 122 individuals were identified; 65 had reported on the direction of the association between birth weight and total blood cholesterol. Although regression coefficients were published for only 11 studies and other quantitative estimates for 3 other studies, regression coefficients (published or unpublished) were obtained for 58 studies among 68 974 individuals. Data Synthesis Inverse associations were observed in 11 of 14 studies that had previously published quantitative estimates but in only 18 of the remaining 51 that had reported on the direction of this association (heterogeneity P = .004). Similarly, the weighted estimate for the 11 studies was –1.89 mg/dL (–0.049 mmol/L) total cholesterol per kilogram birth weight compared with –0.69 mg/dL (–0.018 mmol/L) per kilogram for 47 studies that provided unpublished regression coefficients (heterogeneity P = .009). Overall, the weighted estimate from the 58 contributing studie...
ACCESSION #
15285750

 

Related Articles

  • Rehospitalization of Extremely Low Birth Weight (ELBW) Infants: Are There Racial/Ethnic Disparities? Morris, Brenda H; Gard, Charlotte C; Kennedy, Kathleen // Journal of Perinatology;Oct2005, Vol. 25 Issue 10, p656 

    BACKGROUND:Premature infants are at increased risk for rehospitalization after discharge from the hospital. Racial disparities are known to exist in pediatric health care.OBJECTIVE:To evaluate whether racial disparities exist in the proportion of extremely low birth weight (ELBW) infants...

  • Does facility-based newborn care improve neonatal outcomes? A review of evidence. Neogi, Sutapa; Malhotra, Sumit; Zodpey, Sanjay; Mohan, Pavitra // Indian Pediatrics;Aug2012, Vol. 49 Issue 8, p651 

    Context: Facility based newborn care is gaining importance as an intervention aiming at reduction of neonatal mortality. Objective: To assess different factors that affect effectiveness of facility based newborn care on neonatal outcomes. Evidence acquisition: Electronic search using key search...

  • New Evidence Confirms Link Between Low-Birthweight Babies and Smoking. Gursky, Daniel // Education Week;4/29/1992, Vol. 11 Issue 32, p10 

    The article reports on the extensive new data from federal health officials in Washington which confirms that pregnant women who smoke are much more likely than nonsmokers to deliver low-birth weight babies. The National Center for Health Statistics emphasized that the result is the single most...

  • Did Low Birthweight among US Blacks Really Increase? David, Richard J. // American Journal of Public Health;Apr1986, Vol. 76 Issue 4, p380 

    Abstract: The low birthweight (LBW) rate among reported United States non-White births increased 32 per ¢ from 1950 to 1967. States with large increments in non-White LBW rates over the period 1950-67 ("rising LBW states") were compared to states with more stable LBW rates. Paradoxically,...

  • Screening for intrauterine growth retardation using ratio of mid-arm circumference to occipitofrontal circumference. Meadows, N.J.; Till, J.; Leaf, A.; Hughes, E.; Jani, B.; Larcher, V. // British Medical Journal (Clinical Research Edition);4/19/1986, Vol. 292 Issue 6527, p1039 

    Evaluates intrauterine growth retardation by measuring mid-arm circumference and occipitofrontal circumference. Determination of growth retardation in multiethnic population; Ratio of mid-arm circumference to occipitofrontal circumference of infants small for gestational age; Significance of...

  • Drug misuse in pregnancy: losing sight of the baby? McGlone, L.; Mactier, H.; Weaver, L. T. // Archives of Disease in Childhood;Sep2009, Vol. 94 Issue 9, p708 

    Maternal drug misuse can seriously affect the health of the fetus and newborn infant. The association of maternal drug misuse with prematurity, intrauterine growth restriction (IUGR) and neonatal abstinence syndrome (NAS) is well recognised, and there is growing concern about infant visual...

  • An Investigation of Paternity Status and Other Factors Associated with Racial and Ethnic Disparities in Birth Outcomes in Milwaukee, Wisconsin. Ngui, Emmanuel; Cortright, Alicia; Blair, Kathleen // Maternal & Child Health Journal;Jul2009, Vol. 13 Issue 4, p467 

    Objective To examine factors associated with preterm birth and low birthweight and the role of paternity status in birth outcomes among racial/ethnic groups in Milwaukee. Methods Retrospective analysis of data on 151,869 singleton live births (1993--2006) from the City of Milwaukee, Wisconsin....

  • The effect of maternal stress on birth outcomes: exploiting a natural experiment. Torche, Florencia // Demography;Nov2011, Vol. 48 Issue 4, p1473 

    A growing body of research highlights that in utero conditions are consequential for individual outcomes throughout the life cycle, but research assessing causal processes is scarce. This article examines the effect of one such condition-prenatal maternal stress-on birth weight, an early outcome...

  • Prophylactic fluconazole for very low birthweight infants.  // Archives of Disease in Childhood;Nov2007, Vol. 92 Issue 11, p1023 

    The article reports on the prophylactic fluconazole for very low birthweight (VLBW) infants in Europe. Survey shows a colonization rates of up to 60 percent for candida species among VLBW infants in neonatal intensive care units (NICUs). It was found out that the invasive fungal infection may...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics