The Influence of Angiographic Endpoints on the Outcome of Lipid Intervention Studies

Jukema, J. Wouter; van Boven, Ad J.; Zwinderman, Aeilko H.; Bal, Egbert T.; Reiber, Johan H. C.; Bruschke, Albert V. G.
July 1996
Angiology;Jul1996, Vol. 47 Issue 7, p633
Academic Journal
The aims of this study were to evaluate the influence of different coronary angiographic endpoints on the outcome of lipid intervention studies and to formulate a proposal for angiographic endpoint standardization. In recent angiographic intervention studies a confusing diversity in angiographic endpoints has been used to determine the outcome. In addition, differences in study populations (eg, bypass patients included or not) could influence results. This makes comparisons between studies cumbersome and raises the question to what extent the results of various studies may be subject to the selection of angiographic endpoints. The investigators compared three frequently used endpoints (mean segment diameter, minimum obstruction diameter, and % stenosis) in a group of 505 patients who had just finished a trial designed to assess the effect of cholesterol lowering by pravastatin. To exclude a potential bias this analysis was carried out at the time that the study was still blinded.


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