Use Of [14C]-sodium bicarbonate/urea to measure total energy expenditure in overweight men and women before and after low calorie diet induced weight loss

Luscombe, Natalie D.; Tsopelas, Christopher; Bellon, Max; Clifton, Peter M.; Kirkwood, Ian; Wittert, Gary A.
September 2006
Asia Pacific Journal of Clinical Nutrition;Sep2006, Vol. 15 Issue 3, p307
Academic Journal
The aim of this study was to evaluate the use of the [14C]-sodium bicarbonate/urea technique to measure the change in total energy expenditure after weight loss and a period of weighht maintenance. Eleven health subjects (6 men and 5 women aged 50 ± 3 yrs, BMI 34.1 ± 2.1 kg/m², body fat 38.7 ± 3%) underwent 8 weeks of energy restriction using a combination of 'Modifast™' formula and one small meal per day (≈3.3 MJ/day). For an additional 2-weeks, subjects resumed a solid food diet that contained enough energy to stabilize body weight at the newly reduced level. Body composition, total energy expenditure (TEE), resting energy expenditure (REE) and the thermic effect of a 2.7 MJ test meal (TEF) were measured at both weeks 0 and 10. At week 10 as compared to week 0, body weight decreased by 12.2 ± 1.6 kg (12.5%) (P < 0.001). Total fat and lean mass decreased by 8.4 ± 1.0 kg (20.4%) and 3.8 ± 0.7 kg (6.7%), respectively (P < 0.001). REE decreased by 500 ± 128 kJ/day (5.6 ± 1.3%) (P < 0.002). Decreases in the TEE (0.18 ± 3.7%) and TEF (1.4 ± 0.9%) were not significant. In conclusion, although [14C]-sodium bicarbonate/urea was well tolerated and did not interfere with normal daily activities, it did not have sufficient sensitivity to accurately measure weight loss induced changes in TEE in the range of 0.1-10%.


Related Articles

  • Self-Reported Versus Actual Caloric Intake.  // Journal of Aging & Physical Activity;Oct1993, Vol. 1 Issue 1, p87 

    The article discusses the study which examines the impact of self-reported diet resistance and daily actual caloric intake on losing weight. Researchers used doubly labeled water, which provides an accurate value estimate of total energy expenditure and measured the components of daily energy...

  • Nuts and healthy body weight maintenance mechanisms. Mattes, Richard D.; Dreher, Mark L. // Asia Pacific Journal of Clinical Nutrition;Mar2010, Vol. 19 Issue 1, p137 

    Nuts are rich sources of multiple nutrients and phytochemicals associated with health benefits, including reduced cardiovascular disease risk. This has prompted recommendations to increase their consumption. However, they are also high in fat and are energy dense. The associations between these...

  • Short-term Satiety of High Protein Formula on Obese Subjects: A Pilot Study. Pertiwi, Kamalita; Susana; Kurniati, Astri // International Proceedings of Chemical, Biological & Environmenta;2012, Vol. 39, p42 

    Protein is considered to be the most satiating macronutrients. Therefore, three nutritional formulas differed in protein contribution to energy were developed to assess the satiating properties of higher protein content using subjective satiety ratings in obese subjects. Subjects received...

  • High-level medium-chain triglyceride feeding and energy expenditure in normal-weight women. Alexandrou, Elena; Herzberg, Gene R.; White, Matthew D. // Canadian Journal of Physiology & Pharmacology;May2007, Vol. 85 Issue 5, p507 

    The objective of this study was to assess how short-term feeding of high levels of dietary medium-chain triglyceride (MCT) affect energy expenditure and postprandial substrate oxidation rates in normal-weight, premenopausal women. Eight healthy women were fed both a MCT-rich and an isocaloric...

  • Rates of energy and phosphorus metabolism in Littorina snails (gastropoda). Arakelova, E. // Russian Journal of Ecology;May2012, Vol. 43 Issue 3, p243 

    Energy metabolism and phosphorus excretion were studied in Littorina littorea and L. saxatilis snails from the White Sea. Some elemental components of the body were determined quantitatively, and the rates of oxygen consumption and phosphorus excretion were estimated. All parameters were...

  • Energy expenditure during overfeeding. Joosen, Annemiek M. C. P.; Westerterp, Klaas R. // Nutrition & Metabolism;2006, Vol. 3, p25 

    The large inter-individual variation in weight gain during standardized overfeeding together with a weight gain that is often less than theoretically calculated from the energy excess suggest that there are differences between persons in the capacity to regulate energy expenditure and hence...

  • Energy Expenditure Before and After Roux-en-Y Gastric Bypass. Faria, Silvia; Faria, Orlando; Buffington, Cynthia; Almeida Cardeal, Mariane; Rodrigues de Gouvêa, Heloisa // Obesity Surgery;Sep2012, Vol. 22 Issue 9, p1450 

    Background: Weight loss may decrease the energy expenditure (EE) because of changes in body composition (BC). The reduction in EE may contribute, in part, to weight regain. Experimental studies in animals indicate that Roux-en-Y Gastric Bypass (RYGB) increases the resting metabolic rate (RMR)...

  • Intranasal application of the melanocortin 4 receptor agonist MSH/ACTH(4-10) in humans causes lipolysis in white adipose tissue. Wellhöner, P; Hörster, R; Jacobs, F; Sayk, F; Lehnert, H; Dodt, C // International Journal of Obesity;May2012, Vol. 36 Issue 5, p703 

    Objective:The melanocortin system has a highly significant role in the hypothalamic regulation of body weight and energy expenditure. In animals, intracerebroventricular infusion of melanocortin receptor 4 (MCR-4) agonists increases basal metabolic rate through activation of the sympathetic...

  • Numbers you can trust. Miller, Blake // Women's Health;Oct2008, Vol. 5 Issue 8, p44 

    The article explains the three basic weight-loss measurements. The Daily Caloric Requirement (DRC) simply states that eating 500 fewer calories a day than the body requires will lead to a pound decrease per week. Resting Metabolic Rate tabulates calorie output or the number of calories that a...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics