Twice-daily insulin regimens in management of severe diabetes

Oakley, Nigel; Mather, Hugh; Hadley, Lindsay; Lynch, Janice; Pilkington, Thomas
May 1981
Journal of the Royal Society of Medicine;May1981, Vol. 74 Issue 5, p363
Academic Journal
Diurnal glucose profiles have been compared in ten insulin dependent diabetics receiving, firstly, a twice-daily soluble insulin (SI): isophane insulin (NPHI) regimen containing a high proportion of SI (mean 73%O) and, secondly, Mixtard insulin (30% SI, 70% NPHI). For each patient the two regimens gave similar profiles though nocturnal blood glucose control was better on Mixtard. HbA1 values were similar on the two regimens. The findings show that, using highly purified formulations, small changes in insulin proportions in twice-daily SI: NPHI regimens may be irrelevant to diabetic control; they also suggest that highly purified NPHI may have a substantially shorter duration of action than its older counterpart and that the convenient regimen of twice-daily Mixtard is usually as good as any more complicated ‘tailormade’ regimen of highly purified insulins.


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