Editorial [Hot Topic:Dietary Determinants of the Metabolic Syndrome (Guest Editor: Luc Tappy Co-Editors: Jacques Delarue and Kim-Anne Le)]

Tappy, Luc; Delarue, Jacques; L�, Kim-Anne
June 2007
Current Nutrition & Food Science;2007, Vol. 3 Issue 2, p109
Academic Journal
Over the past decades, there has been a tremendous rise in the prevalence of obesity, not only in the westernized countries, but all over the world. Although it is well recognized that genetic factors are involved in obesity, this rapid rise is essentially to be attributed to environmental factors; indeed, the human gene pool is unlikely to have changed substantially over such a short period! However, this does not exclude that inside this gene pool some genes may be more expressed or repressed in response to environmental factors, which may in turn lead to metabolic disorders. In this regard, the observation that a Paleolithic diet confers, at least in domestic pigs, a higher insulin sensitivity, a lower blood pressure and a lower C reactive protein level (a surrogate marker of cardiovascular risk) as compared to a cereal-based diet may also be of some interest in an evolutionary perspective [1].


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