TITLE

Cord-Blood Transplantation in Patients with Leukemia – A Real Alternative for Adults

AUTHOR(S)
Sanz, Miguel A.
PUB. DATE
November 2004
SOURCE
New England Journal of Medicine;11/25/2004, Vol. 351 Issue 22, p2328
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article discusses the use of umbilical cord blood for transplant in patients with leukemia. If patients do not receive the needed transplant in time, umbilical-cord blood can be used, and acceptable cord-blood units can be identified for most patients, because less stringent HLA compatibility with the recipient is required. The main obstacles to more widespread use of cord-blood transplantation in adults have been the risks of graft failure and delayed hematopoietic recovery, both due primarily to an imbalance between the body size of most adult recipients and the number of hematopoietic progenitor cells in a cord-blood unit, which is about 1/10 the number in a marrow harvest. Several studies are mentioned.
ACCESSION #
24906917

 

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