Overweight Youth: Low Prevalence of Glucose Intolerance and Diabetes

Crimmins, Nancy A.; Khoury, Jane C.; Daniels, Stephen R.; D'Alessio, David A.; Dolan, Lawrence M.; Kirk, Shelley
June 2007
Diabetes;Jun2007 Supplement 1, Vol. 56, pA470
Academic Journal
A clear and alarming trend exists for increasing rates of obesity in children and adolescents. Previous reports have suggested that overweight children and adolescents have rates of glucose intolerance and type 2 diabetes (T2DM) as high as 25% and 4% respectively, raising the specter of a pediatric diabetes epidemic. To further define the risk of abnormalities in carbohydrate metabolism in this group, we determined the prevalence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and T2DM in 278 overweight children and adolescents consecutively enrolled in a tertiary weight management program (from 02/2003 through 07/2006). The descriptive characteristics of the subjects at enrollment are outlined in the table. All subjects were screened by 75 g oral glucose tolerance testing (OGTT) prior to any intervention through the program. By OGTT, 7.9% (22/278) had IFG, 6.1% (17/278) had IGT, and 1.8% (5/278) had both IFG and IGT. Two individuals had normal fasting glucose, but a 2 hour glucose ≥200 mg/dL (0.7%). One individual (0.4%) had both a fasting glucose ≥126 mg/dL and a 2 hour glucose ≥200 mg/dL and was diagnosed with T2DM. The overall prevalence of any abnormal glucose value in the study population was 13.3% (37/278). These findings demonstrate that the prevalence of abnormal glucose metabolism in a high-risk population of children and adolescents is lower than previously reported. Despite increasing rates of obesity, rates of diabetes and IGT are still substantially lower in youth than in adults.


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