Colesevelam HCI Improves Glycemic Control, Independent of Age, in Patients with Type 2 Diabetes Uncontrolled on Metformin, Sulfonylurea, or Insulin-Based Therapy

Ovalle, Fernando; Philis-Tsimikas, Athena; Truitt, Kenneth; Dmuchowski, Carl; Jones, Michael
June 2007
Diabetes;Jun2007 Supplement 1, Vol. 56, pA536
Academic Journal
The article discusses studies which examined the effects of Colesevelam HC1 (COL), a bile acid sequestrant indicated to lower low-density lipoprotein cholesterol, versus placebo (PL) when combined with metformin, sulfonylurea or insulin-based therapy. A pilot study showed that COL improves the lipid profile and glycemic control when added to an established antidiabetic regimen in patients with type 2 diabetes mellitus (T2DM). Also reported is the analysis of glycemic control based on age.


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