Metformin Improved Glycemic Control in Patients with Type 1 Diabetes

Gottlieb, Peter A.; Ellis, Samuel L.; Lopez, Phillip; Gutin, Raymond; Garg, Satish K.
June 2007
Diabetes;Jun2007 Supplement 1, Vol. 56, pA574
Academic Journal
The purpose of this study was to evaluate glycemic control in adult patients with type 1 diabetes prescribed to metformin therapy from January 2000 to December 2005. Secondary outcomes included weight, BMI, and insulin dose. This was a retrospective study with a computer matched control group in patients with type 1 diabetes A total of 59 patients were included in this analysis. The control group was matched for age, gender, AIC and weight. The number of subjects on metformin included in the pre-post data analysis was 48, 40, 37 and 38 at 3, 6, 9 and 12 months, respectively. A separate analysis was conducted using a matched control group of 41 patients. Baseline characteristics included 40 (68%) women; mean age of 31.5 ± 10.4 years, A1C of 8.19 ± .1.42% and a BMI of 31.7 ± 5 kg/m² in the metformin group. Pre-post analysis of the 59 patients on metformin was performed at 3, 6, 9 and 12 months. A significant reduction in A1c was observed at 3 months (8.08 vs. 7.64%; p<0.001). A non-significant mean reduction in A1C of 0.35, 0.27 and 0.28 percent was observed at 6, 9 and 12 months, respectively. A significant reduction in weight was observed at 6 (200.2 vs. 197.5 pounds; p=0.01), 9 (202.2 vs. 198.5 pounds; p=0.008) and 12 months (204.4 vs. 200.1 pounds; p=0.003). Insulin requirements (units/kg) were significantly reduced at 3 and 6 months (p<0.02). In comparison to the control group a significant reduction in mean A1c was also observed at 3 months with metformin (0.53%; p=0.017). In conclusion overweight patients with type 1 diabetes initiated on metformin therapy had significant reductions in A1C, weight and insulin dose.


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