Short Insulin Tolerance Test May Determine Thiazolidinediones Treatment in Type 2 Diabetes

Lee, Mi Y.; Koh, Jang H.; Jung, Pil M.; Shim, Myoung S.; Kim, Mi J.; Shin, Jang Y.; Shin, Young G.; Chung, Choon H.
June 2007
Diabetes;Jun2007 Supplement 1, Vol. 56, pA578
Academic Journal
The short insulin tolerance test is a simple and reliable method of estimating insulin sensitivity. This study was designed to compare the insulin sensitizing effects of thiazolidinediones (TZDs) on the degree of insulin resistance determined by short insulin tolerance test, Kitt in type 2 diabetes. Eighty three subjects (mean age = 57.87 ± 10.78) with type 2 diabetes were enrolled and received 4mg of rosiglitazone or 15mg of pioglitazone single dose daily. The mean follow-up duration was 25.39 ± 9.66 months. We assessed insulin sensitivity using insulin tolerance test before and after TZDs treatment. When we compared the characteristics before and after TZDs treatment, mean fasting glucose level significantly decreased (183.27 ± 55.04 to 137.35 ± 36.42 mg/dL, p<0.001) and mean HbA1C level significantly decreased (9.24 ± 1.96 to 8.11 ± 1.39%, p<0.001). Also, Kitt values were significantly increased (2.23 ± 1.14 to 2.67 ± 0.97 %/min, p=0.003) and HOMA-IR was significantly decreased (2.98±0.68 to 1.04±0.24, p<0.05). In conclusion, TZDs have glucose lowering effects through improvement of insulin resistance proved by short insulin tolerance test. Short insulin tolerance test may benefit to determine the effects of TZDs in type 2 diabetes.


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