Aseptic Meningitis Associated With Cephalosporins in an Infant With Trisomy 21

Nakajima, Wako; Ishida, Akira; Takahashi, Maya; Sato, Yoko; Ito, Tomoo; Takada, Goro
June 2007
Journal of Child Neurology;Jun2007, Vol. 22 Issue 6, p780
Academic Journal
The authors report a case of aseptic meningitis associated with cephalosporins in an infant. A 1 -year-old boy with trisomy 21 received several antimicrobials including cefotaxime and ceftriaxone for bacterial meningitis caused by Haemophilus influenzae b. High fever continued for more than a month, and discontinuation of cefotaxime broke the fever and improved the findings of cerebrospinal fluid. Because third-generation cephalosporitis are the first choice against bacterial meningitis for infants, recognition and diagnosis of this rare occurrence of drug-induced aseptic meningitis is important. It is treatable by withdrawal of the drug, and recurrence can be prevented.


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