TITLE

A clonogenic common myeloid progenitor that give rise to all myeloid lineages

AUTHOR(S)
Akashi, Koichi; Traver, David
PUB. DATE
March 2000
SOURCE
Nature;3/9/2000, Vol. 404 Issue 6774, p193
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Identifies a clonogenic common lymphoid progenitor from hematopoietic stem cells that can differentiate into T, B and natural killer cells but not myeloid cells. Use of cell-surface markers and flow cytometry to identify a common myeloid progenitor; Expression profile of hematopoiesis-related genes; Reflection of earliest branch points between lymphoid and myeloid lineages.
ACCESSION #
2950940

 

Related Articles

  • Conclusions of a national multicenter intercomparative study of in vitro cultures of human hematopoietic progenitors. Lamana, M; Albella, B; Rodríguez, F; Regidor, C; Bueren, J A // Bone Marrow Transplantation;2/15/99, Vol. 23 Issue 4, p373 

    With the aim of developing a standardized program of clonogenic cultures, a multicenter intercomparative study of human CFU-GM, BFU-E and CFU-GEMM cultures was conducted. Aliquots of fresh mononuclear cord blood cells, as well as uniform culture materials and instructions for cell culture and...

  • Stroma-conditioned medium and sufficient prestimulation improve fibronectin fragment-mediated retroviral gene transfer into human primitive mobilized peripheral blood stem cells through effects on their recovery and transduction efficiency. Breems, D A; Van Driel, E M; Hawley, R G; Siebel, K E; Ploemacher, R E // Leukemia (08876924);Jun98, Vol. 12 Issue 6, p951 

    Mobilized peripheral blood stem cells (PBSC) are an attractive vehicle for cancer gene therapy. However these stem cells may have a reduced proliferative capacity due to previous cytotoxic chemotherapy treatment of the patient. In addition, primitive hematopoietic stem cells (HSC) from mobilized...

  • Stem cells: Histone deacetylase inhibitors for stem cell boost. Burgess, Darren J. // Nature Reviews Genetics;Jun2014, Vol. 15 Issue 6, p364 

    The article reports on a study by P. Chaurasia and colleagues that explores the human umbilical chord blood cells which are limited source of haematopoietic stem cells for transplantation among allogeneic recipients suffering from haemotopoietic abnormalities.

  • Clarifying the properties of endothelium.  // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Jul2005, Vol. 11 Issue 1, p85 

    Clarifies the properties of blast-forming cells and their genetic control of the endothelium. Emergence of hematopoietic stem cells (HSC) in para-aortic splanchnopleur; Physiological role of the stem cell leukemia gene in mice; Factors associated with HSC formation.

  • When and How to Treat Essential Thrombocythemia. Barbui, Tiziano; Finazzi, Guido // New England Journal of Medicine;7/7/2005, Vol. 353 Issue 1, p85 

    Comments on how to treat essential thrombocythemia, which involves clonal hematopoietic stem cells. Details of risk factors for thrombotic events in patients with essential thrombocythemia including age; Use of hydroxyurea as a treatment for thrombocythemia; Details of a study conducted by...

  • Genetic programs regulating HSC specification, maintenance and expansion. Lessard, Julie; Faubert, Am�lie; Sauvageau, Guy // Oncogene;9/20/2004 Review, Vol. 23 Issue 43, p7199 

    All mature blood cells originate from a small population of self-renewing pluripotent hematopoietic stem cells (HSCs). The capacity to self-renew characterizes all stem cells, whether normal or neoplastic. Interestingly, recent studies suggest that self-renewal is essential for tumor cell...

  • Rescue from failed growth factor and/or chemotherapy HSC mobilization with G-CSF and plerixafor (AMD3100): an institutional experience. Fowler, C. J.; Dunn, A.; Hayes-Lattin, B.; Hansen, K.; Hansen, L.; Lanier, K.; Nelson, V.; Kovacsovics, T.; Leis, J.; Calandra, G.; Maziarz, R. T. // Bone Marrow Transplantation;Jun2009, Vol. 43 Issue 12, p909 

    Auto-SCT has been shown to be a potentially curative treatment for a variety of hematological malignancies. Auto-SCT is dependent on the successful mobilization and collection of hematopoietic stem cells to ensure engraftment. The inability to mobilize sufficient number of hematopoietic stem...

  • Self-Renewal of Single Mouse Hematopoietic Stem Cells Is Reduced by JAK2V617F Without Compromising Progenitor Cell Expansion. Kent, David G.; Li, Juan; Tanna, Hinal; Fink, Juergen; Kirschner, Kristina; Pask, Dean C.; Silber, Yvonne; Hamilton, Tina L.; Sneade, Rachel; Simons, Benjamin D.; Green, Anthony R. // PLoS Biology;Jun2013, Vol. 11 Issue 6, p1 

    : In this study, single cell assays and mathematical modeling demonstrate that a single oncogenic point mutation can negatively affect hematopoietic stem cells while leaving progenitor cell expansion intact.

  • DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Bröske, Ann-Marie; Vockentanz, Lena; Kharazi, Shabnam; Huska, Matthew R.; Mancini, Elena; Scheller, Marina; Kuhl, Christiane; Enns, Andreas; Prinz, Marco; Jaenisch, Rudolf; Nerlov, Claus; Leutz, Achim; Andrade-Navarro, Miguel A.; Jacobsen, Sten Eirik W.; Rosenbauer, Frank // Nature Genetics;Nov2009, Vol. 41 Issue 11, p1207 

    DNA methylation is a dynamic epigenetic mark that undergoes extensive changes during differentiation of self-renewing stem cells. However, whether these changes are the cause or consequence of stem cell fate remains unknown. Here, we show that alternative functional programs of hematopoietic...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics