Review: Improving Outcomes for Patients with Burkitt Lymphoma and HIV

Blinder, Victoria S.; Chadburn, Amy; Furman, Richard R.; Mathew, Susan; Leonard, John P.
March 2008
AIDS Patient Care & STDs;Mar2008, Vol. 22 Issue 3, p175
Academic Journal
Burkitt lymphoma (BL) is a highly aggressive B-cell malignancy that occurs with increased frequency among patients infected with HIV. Until recently, the immunocompromised state of patients with HIV and BL was generally deemed to preclude the use of the intensive chemotherapeutic regimens used to treat HIV-negative patients due to toxicity issues. However, the advent of highly active antiretroviral therapy (HAART) and the mounting evidence that less intensive lymphoma regimens are ineffective in BL have led investigators to treat HIV-positive patients with the same chemotherapy now established as the standard of care for immunocompetent patients. Data suggest that these current approaches, along with supportive care, may result in improved patient outcomes. In contrast, the role of adjunctive immunotherapy with rituximab in HIV-BL remains undefined. Further studies, including randomized clinical trials, are needed to better delineate the optimal treatment for patients with this devastating disease.


Related Articles

  • Darunavir. McKeage, Kate; Perry, Caroline M.; Keam, Susan J. // Drugs;2009, Vol. 69 Issue 4, p477 

    Darunavir is an oral nonpeptidic HIV-1 protease inhibitor (PI) that is used, together with a low boosting dose of ritonavir, as part of an antiretroviral therapy (ART) regimen in treatment-experienced and -naive patients with HIV-1 infection. Compared with early-generation PIs, boosted darunavir...

  • Normalization of B Cell Counts and Subpopulations after Antiretroviral Therapy in Chronic HIV Disease. Moir, Susan; Malaspina, Angela; Ho, Jason; Wei Wang; DiPoto, Angela C.; O'Shea, Marie A.; Roby, Gregg; Mican, Joann M.; Kottilil, Shyam; Tae-Wook Chun; Proschan, Michael A.; Fauci, Anthony S. // Journal of Infectious Diseases;2/15/2008, Vol. 197 Issue 4, p572 

    Background. Untreated human immunodeficiency virus (HIV) disease leads to abnormalities in all major lymphocyte populations, including CD4+ T cells, CD8+ T cells, and B cells. However, little is known regarding the effect of antiretroviral therapy (ART)-induced decrease in HIV viremia on B cell...

  • Antiretroviral Therapy in the Real World: Population-Based Pharmacoeconomic Analysis of Administration of Anti-HIV Regimens to 990 Patients. Sabbatani, Sergio; Manfredi, Roberto; Biagetti, Carlo; Chiodo, Francesco // Clinical Drug Investigation;2005, Vol. 25 Issue 8, p527 

    Objective and methods: The aim of our study was to analyse retrospectively the nature and frequency of antiretroviral prescriptions for 990 HIV-infected patients followed at our outpatient centre in Bologna, Italy, from January 2003 to March 2004. The main focus of the study was to identify the...

  • Kaposi Sarcoma--Associated Immune Reconstitution Inflammatory Syndrome (IRIS).  // Clinical Infectious Diseases;12/1/2005, Vol. 41 Issue 11, preceding p1 

    This article presents a study which states that immune reconstitution inflammatory syndrome (IRIS) which is associated with Kaposi Sarcoma. Researcher M. Bower and colleagues describe their experience with Kaposi sarcoma--associated IRIS in a cohort of HIV-infected patients at Chelsea and...

  • Life Stress and Adherence to Antiretroviral Therapy among HIV-Positive Individuals: A Preliminary Investigation. Bottonari, Kathryn A.; Roberts, John E.; Ciesla, Jeffrey A.; Hewitt, Ross G. // AIDS Patient Care & STDs;Nov2005, Vol. 19 Issue 11, p719 

    The present study sought to investigate the impact of life stress on treatment adherence and viral load of HIV-positive individuals. Three different aspects of life stress were examined in this investigation (perceived stress, acute life events unrelated to the HIV illness, and HIVrelated acute...

  • Delayed Progression to Death and to AIDS in a Hong Kong Cohort of Patients with Advanced HIV Type 1 Disease During the Era of Highly Active Antiretroviral Therapy. Ka Hing Wong; Kenny Chi Wai Chan; Shui Shan Lee // Clinical Infectious Diseases;9/15/2004, Vol. 39 Issue 6, p853 

    Background. The magnitude of the impact of highly active antiretroviral therapy (HAART) since its introduction in non-Western countries is not entirely clear. We studied disease progression among adult patients with advanced human immunodeficiency virus type 1 (HIV-1) infection in the pre-HAART...

  • Providing antiretroviral treatment in Thailand.  // Report on the Global HIV/AIDS Epidemic: UNAIDS - 2004;1/1/2004, p106 

    The article offers information on the antiretroviral treatment program in Thailand. According to the author, lower drug prices have contributed to a fivefold increase in the number of human immunodeficiency virus (HIV)-positive patients receiving antiretroviral treatment in the country. It was...

  • Antiretroviral therapy has not extended survival of patients with HIV-associated lymphoma.  // Infectious Disease News;Sep2013, Vol. 26 Issue 9, p47 

    The article reports on the stable survival rate for patients with Human immunodeficiency virus (HIV)-associated lymphoma since the incorporation of antiretroviral therapy in standard patient care, which according to Dr. Satish Gopal of the University of North Carolina was surprising and quite...

  • Plasma HIV Load and Proviral DNA Decreases After Two Standard Antiretroviral Regimens in HIV-Positive Patients Naive to Antiretrovirals. Torti, Carlo; Quiros-Roldan, Maria Eugenia; Cologni, Giuliana; Nichelatti, Michele; Ceresoli, Francesca; Pinti, Marcello; Nasi, Milena; Cossarizza, Andrea; Lapadula, Giuseppe; Costarelli, Silvia; Manca, Nino; Gargiulo, Franco; Magoni, Michele; Carosi, Giampiero // Current HIV Research;Jan2008, Vol. 6 Issue 1, p43 

    (i) To compare early decrease of HIV plasma viral load (pVL) after two standard combinations of highly active antiretroviral therapy (HAART). (ii) To evaluate variations of proviral HIV-DNA load on conditions of sustained pVL undetectability. Two different sub-studies of a multicentre...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics