TITLE

Normalization of B Cell Counts and Subpopulations after Antiretroviral Therapy in Chronic HIV Disease

AUTHOR(S)
Moir, Susan; Malaspina, Angela; Ho, Jason; Wei Wang; DiPoto, Angela C.; O'Shea, Marie A.; Roby, Gregg; Mican, Joann M.; Kottilil, Shyam; Tae-Wook Chun; Proschan, Michael A.; Fauci, Anthony S.
PUB. DATE
February 2008
SOURCE
Journal of Infectious Diseases;2/15/2008, Vol. 197 Issue 4, p572
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. Untreated human immunodeficiency virus (HIV) disease leads to abnormalities in all major lymphocyte populations, including CD4+ T cells, CD8+ T cells, and B cells. However, little is known regarding the effect of antiretroviral therapy (ART)-induced decrease in HIV viremia on B cell numbers and subpopulations. Methods. We conducted a longitudinal study to evaluate changes in B cell numbers and subpopulations that occur during the course of 12 months of effective ART in a group of individuals with chronic HIV infection. Results. ART-induced decrease in HIV viremia was associated with a significant increase in B cell counts, similar to increases in CD4+ T cell counts yet distinct from the lack of increase in CD8+ T cells. The increase in B cell counts was accompanied by a significant decrease in the frequency of apoptosis-prone B cell subpopulations, namely mature activated and immature transitional B cells, which are overrepresented in untreated HIV disease. The increase in B cell counts was reflected by a significant increase in naive and resting memory B cells, both of which represent populations that are essential for generating adequate humoral immunity. Conclusions. Normalization of B cell counts and subpopulations may help to explain the improvement in humoral immunity reported to occur after an ART-induced decrease in HIV viremia.
ACCESSION #
31472913

 

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