TITLE

CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1–infected individuals

AUTHOR(S)
Ahuja, Sunil K.; Kulkarni, Hemant; Catano, Gabriel; Agan, Brian K.; Camargo, Jose F.; Weijing He; O'Connell, Robert J.; Marconi, Vincent C.; Delmar, Judith; Eron, Joseph; Clark, Robert A.; Frost, Simon; Martin, Jeffrey; Ahuja, Seema S.; Deeks, Steven G.; Little, Susan; Richman, Douglas; Hecht, Frederick M.; Dolan, Matthew J.
PUB. DATE
April 2008
SOURCE
Nature Medicine;Apr2008, Vol. 14 Issue 4, p413
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The basis for the extensive variability seen in the reconstitution of CD4+ T cell counts in HIV-infected individuals receiving highly active antiretroviral therapy (HAART) is not fully known. Here, we show that variations in CCL3L1 gene dose and CCR5 genotype, but not major histocompatibility complex HLA alleles, influence immune reconstitution, especially when HAART is initiated at <350 CD4+ T cells/mm3. The CCL3L1-CCR5 genotypes favoring CD4+ T cell recovery are similar to those that blunted CD4+ T cell depletion during the time before HAART became available (pre-HAART era), suggesting that a common CCL3L1-CCR5 genetic pathway regulates the balance between pathogenic and reparative processes from early in the disease course. Hence, CCL3L1-CCR5 variations influence HIV pathogenesis even in the presence of HAART and, therefore, may prospectively identify subjects in whom earlier initiation of therapy is more likely to mitigate immunologic failure despite viral suppression by HAART. Furthermore, as reconstitution of CD4+ cells during HAART is more sensitive to CCL3L1 dose than to CCR5 genotypes, CCL3L1 analogs might be efficacious in supporting immunological reconstitution.
ACCESSION #
31546568

 

Related Articles

  • Normalization of B Cell Counts and Subpopulations after Antiretroviral Therapy in Chronic HIV Disease. Moir, Susan; Malaspina, Angela; Ho, Jason; Wei Wang; DiPoto, Angela C.; O'Shea, Marie A.; Roby, Gregg; Mican, Joann M.; Kottilil, Shyam; Tae-Wook Chun; Proschan, Michael A.; Fauci, Anthony S. // Journal of Infectious Diseases;2/15/2008, Vol. 197 Issue 4, p572 

    Background. Untreated human immunodeficiency virus (HIV) disease leads to abnormalities in all major lymphocyte populations, including CD4+ T cells, CD8+ T cells, and B cells. However, little is known regarding the effect of antiretroviral therapy (ART)-induced decrease in HIV viremia on B cell...

  • Plasma HIV Load and Proviral DNA Decreases After Two Standard Antiretroviral Regimens in HIV-Positive Patients Naive to Antiretrovirals. Torti, Carlo; Quiros-Roldan, Maria Eugenia; Cologni, Giuliana; Nichelatti, Michele; Ceresoli, Francesca; Pinti, Marcello; Nasi, Milena; Cossarizza, Andrea; Lapadula, Giuseppe; Costarelli, Silvia; Manca, Nino; Gargiulo, Franco; Magoni, Michele; Carosi, Giampiero // Current HIV Research;Jan2008, Vol. 6 Issue 1, p43 

    (i) To compare early decrease of HIV plasma viral load (pVL) after two standard combinations of highly active antiretroviral therapy (HAART). (ii) To evaluate variations of proviral HIV-DNA load on conditions of sustained pVL undetectability. Two different sub-studies of a multicentre...

  • Antiretroviral Drugs in Pediatric HIV-Infected Patients. Phelps, B. Ryan; Rakhmanina, Natella // Pediatric Drugs;2011, Vol. 13 Issue 3, p175 

    Antiretroviral (ARY) therapy has been shown to achieve high therapeutic efficacy in treating pediatric HLV disease. The delivery of affordable, child friendly, and easy to store and administer ARV drugs is key to the successful management of HIV in children. In recent years, significant progress...

  • Immune reconstitution syndrome leading to fatal invasive cerebral aspergillosis: case report.  // Reactions Weekly;7/16/2005, Issue 1060, p6 

    The article presents a case of an HIV-infected man with fatal invasive cerebral aspergillosis associated with immune reconstitution syndrome after starting antiretroviral therapy. The man received other medical treatment after weeks of antiretroviral therapy. Medical history and condition of the...

  • Providing antiretroviral treatment in Thailand.  // Report on the Global HIV/AIDS Epidemic: UNAIDS - 2004;1/1/2004, p106 

    The article offers information on the antiretroviral treatment program in Thailand. According to the author, lower drug prices have contributed to a fivefold increase in the number of human immunodeficiency virus (HIV)-positive patients receiving antiretroviral treatment in the country. It was...

  • Quantifying HIV for Monitoring Antiretroviral Therapy in Resource-Poor Settings. Stevens, Wendy S.; Scott, Lesley E.; Crowe, Suzanne M. // Journal of Infectious Diseases;4/15/2010 Supplement 1, Vol. 201, pS16 

    There is increasing evidence to support the inability of CD4 cell count monitoring to predict virological failure in human immunodeficiency virus-infected individuals receiving antiretroviral therapy. There is renewed interest in improving access to viral load monitoring in resource-constrained...

  • A Microsimulation of the Cost-effectiveness of Maraviroc for Antiretroviral Treatment-Experienced HIV-Infected Individuals. Kühne, Felicitas C.; Chancellor, Jeremy; Mollon, Patrick; Myers, Daniela E.; Louie, Michael; Powderly, William G. // HIV Clinical Trials;Mar/Apr2010, Vol. 11 Issue 2, p80 

    Purpose: Maraviroc (MVC) is the first approved CCR5 antagonist. The aim of this study was to explore the cost-effectiveness of MVC in treatment-experienced or treatment-resistant HIV-infected adults.Methods: The validated HIV microsimulation model ARAMIS was used to predict clinical and economic...

  • Five-Year Outcomes of the China National Free Antiretroviral Treatment Program.  // Annals of Internal Medicine;8/18/2009, Vol. 151 Issue 4, pI-42 

    The article presents a study on the rate of recovery of patients in the National Free Antiretroviral Treatment Program in China after five years. It notes that 48,785 patients with HIV were enrolled in the program under the highly active antiretroviral therapy. It mentions that after 6 months of...

  • The Effect of a Multidisciplinary Program on HAART Adherence. Frick, Pamela; Tapia, Kenneth; Grant, Philip; Novotny, Martina; Kerzee, Jane // AIDS Patient Care & STDs;Jul2006, Vol. 20 Issue 7, p511 

    Although emerging evidence suggests differing interventions may improve antiretroviral adherence, there has not been a formal evaluation to identify the impact of a clinic-based multidisciplinary program designed to provide education and identify and correct potential adherence barriers prior to...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics