Mycophenolate mofetil versus cyclophosphamide for inducing remission of ANCA vasculitis with moderate renal involvement

Weixin Hu; Chunbei Liu; Honglang Xie; Huiping Chen; Zhihong Liu; Leishi Li
April 2008
Nephrology Dialysis Transplantation;Apr2008, Vol. 23 Issue 4, p1307
Academic Journal
Objective. We performed a single-centre non-blinded clinical trial to compare the clinical efficacies of mycophenolate mofetil (MMF) and intermittent cyclophosphamide (CTX) pulse therapy as induction treatments in patients with antineutrophil cytoplasmic antibody (ANCA) vasculitis (AAV) and moderate renal involvement. Methods. Patients with active AAV and serum creatinine Results. A total of 35 patients (15 male, 20 female: aged 49.1 ± 12.2 years) were enrolled, with 18 in the MMF group and 17 in the CTX group. Of the 35 patients, 28 were MPO-ANCA positive and 2 were PR3-ANCA positive. Four patients were lost to follow-up in the CTX group. At Month 6, BVAS scores were much lower in the MMF group than in the CTX group (0.2 ± 0.89 versus 2.6 ± 1.7, P Conclusion. Our study suggests that MMF effectively ameliorates disease activity and considerably improves renal function in patients with AAV. Further large-scale multicentre prospective randomized controlled trials will be needed to confirm these findings.


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