SIDA en niños y adolescentes. Un estudio de 34 autopsias en dos décadas

Ridaura-Sanz, Cecilia; De León-Bojorge, Beatriz; López-Corella, Eduardo
November 2007
Acta Pediatrica de Mexico;nov/dic2007, Vol. 28 Issue 6, p270
Academic Journal
Background. Autopsy studies in patients who died with AIDS provide an insight on the occurrence and diversity of tissue changes directly resulting from HIV infection and of the infectious complications, often with opportunistic organisms, associated with the disease. Material and methods. This is a retrospective analysis of 34 autopsies performed in children dying with AIDS at the National Institute of Pediatrics in Mexico City from 1985 to 2004. The cases were classified according to the mechanisms of infection in maternal (prenatal and from breast feeding), transfusion related and from sexual contact. For comparative purposes, the cases were distributed in two decades based on the probable date of infection. Results. Involvement of the lymphoid tissue was the most frequent primary pathology (79%) followed by central nervous system disease in 24 cases (70%). Associated pathology included malnutrition (53%), nephropathy (11.7%), blood vessel involvement (5.8%) and hepatitis (2.9%). Secondary infection was present in every case. Infectious agents included bacteria (55.8%), Cytomegalovirus (44.15%), Pneumocystis (26.4%), Candida (23%), Herpes/Varicella (20%) and Histoplasma (14.7%). Conclusions. A wide variety of tissue changes directly related to HIV infection was found, some of them infrequent complications such as vasculitis. Histoplasmosis was an important cause of death and was not considered as a clinical diagnosis in any of our cases. Mycobacteria, probably non-tuberculous, were found in two patients. Pulmonary Pneumocystis infection is persistently frequent in spite of clinical awareness and prophylactic measures


Related Articles

  • Pneumocystis carinii Pneumonia as a Complication of Immunosuppressive Therapy. Glück, T.; Geerdes-Fenge, H. F.; Straub, R. H.; Raffenberg, M.; Lang, B.; Lode, H.; Schölmerich, J. // Infection;Aug2000, Vol. 28 Issue 4, p227 

    Background: Patients receiving immunosuppressive therapy with corticosteroids and cytotoxic agents may develop opportunistic infections such as Pneumocystis carinii pneumonia (PCP). This indicates a severe T-cell defect, but so far there are no established criteria for identifying patients at...

  • Opportunitstic Infection in Previously Healthy Women. Masur, Henry; Michelis, Mary Ann; Wormser, Gary P.; Lewin, Sharon; Gold, Jon; Tapper, Michael L.; Giron, Jose; Lerner, Chester W.; Armstrong, Donald; Setia, Usha; Sender, Joel A.; Siebken, Robert S.; Nicholas, Peter; Arlen, Zelman; Maayan, Shlomo; Ernst, Jerome A.; Siegal, Frederick P.; Cunningham-Rundles, Susanna // Annals of Internal Medicine;Oct82, Vol. 97 Issue 4, p533 

    Deals with a study which reported the development of Pneumocystis carinii pneumonia and other opportunistic infections in a number of women in New York City. Selection of patients and controls; Patient population; Routine laboratory evaluation; Discussion of results.

  • Improved Treatment For Pneumocystis. Helquist, Michael // Advocate;10/13/87, Issue 483, p23 

    Reports on the efficacy of aerosol pentamidine against pneumocystis carinii pneumonia in persons with AIDS. Absence of side effects; Reduction in average hospital stay.

  • 1995 revised guidelines for prophylaxis against Pneumocystis carinii pneumonia for children...  // MMWR: Morbidity & Mortality Weekly Report;4/28/95 Supplement RR-4, Vol. 44 Issue 16, p1 

    Presents the revised prevention guidelines for prophylaxis against Pneumocystis carinii pneumonia (PCP) for children infected with or perinatally exposed to human immunodeficiency virus (HIV). Recommendations including the prompt diagnosis of children born to HIV-infected women; Timing and...

  • Discontinuation of Primary Prophylaxis for Pneumocystis carinii Pneumonia and Toxoplasmic... Mussini, Cristina; Pezzotti, Patrizio; Govoni, Alessandra; Borghi, Vanni; Antinori, Andrea; d'Arminio Monforte, Antonella; De Luca, Andrea; Mongiardo, Nicola; Cerri, Maria Chiara; Chiodo, Francesco; Concia, Ercole; Bonazzi, Lucio; Moroni, Mauro; Ortona, Luigi; Esposito, Robert; Cossarizza, Andrea; De Rienzo, Bruno // Journal of Infectious Diseases;5/1/2000, Vol. 181 Issue 5, p1635 

    Examines the discontinuation of primary prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in patients infected with HIV-type 1 whose CD4[sup +] T cell counts have increased to 200 cells per cubic millimeter as a result of highly active antiretrovial therapy (HAART). ...

  • Risk Factors for Community-Acquired Pneumonia among Persons Infecte with Human Immunodeficiency... Navin, Thomas R.; Rimland, David; Lennox, Jeffrey L.; Jernigan, John; Cetron, Marty; Hightower, Allen; Roberts, Jacqueline M.; Kaplan, Jonathan E. // Journal of Infectious Diseases;1/1/2000, Vol. 181 Issue 1, p158 

    Analyzes risk factors associated with community-acquired pneumonia among persons infected with HIV. Possible pulmonary damages caused by the antecedent infection; Relationship between the anti-fungal agent fluconazole and the protective effect of the drug to pneumonia; Genetic sequence distinct...

  • Changing Spectrum of HIV Infection and Its Associated Conditions in Spain: The End of the Beginning? Collazos, Julio; Mayo, Jose // AIDS Patient Care & STDs;Jun99, Vol. 13 Issue 6, p347 

    Presents a study which evaluated the long-term influence of different interventions on the natural history of HIV infections, AIDS and associated conditions in Spain. Isoniazid for tuberculosis; Fluconazole for candidiasis; Cotrimoxazole for Pneumocystis carinii pneumonia and toxoplasmosis;...

  • pneumocystis pneumonia. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p615 

    An encyclopedia entry for "pneumocystis pneumonia" is presented. It refers to a lung infection caused by pneumocystis carinii. It is an opportunistic infection that is dangerous to people with impaired resistance to infection. Some of its symptoms are fever, dry cough and shortness of breath....

  • Enzyme-linked immunosorbent assay and serologic responses to Pneumocystis jiroveci. Daly, Kieran R.; Koch, Judy; Levin, Linda; Walzer, Peter D. // Emerging Infectious Diseases;May2004, Vol. 10 Issue 5, p848 

    Seroepidemiologic studies of Pneumocystis pneumonia (PCP) in humans have been limited by inadequate reagents. We have developed an enzyme-linked immunosorbent assay (ELISA) using three overlapping recombinant fragments of the human Pneumocystis major surface glycoprotein (MsgA, MsgB, and MsgC)...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics