TITLE

Reduced respiratory and skeletal muscle strength in survivors of sibling or unrelated donor hematopoietic stem cell transplantation

AUTHOR(S)
Kovalszki, A.; Schumaker, G. L.; Klein, A.; Terrin, N.; White, A. C.
PUB. DATE
June 2008
SOURCE
Bone Marrow Transplantation;Jun2008, Vol. 41 Issue 11, p965
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We performed a retrospective analysis of muscle strength testing obtained following sibling or unrelated donor hematopoietic stem cell transplant (HSCT) between 1 January 1999 and 31 December 2003 in a cohort of 44 subjects at Tufts-New England Medical Center. Maximal inspiratory pressure (PImax) was ?80% predicted in 52% of subjects and ?60% predicted in 20% of subjects; maximal expiratory pressure (PEmax) was ?80% predicted in 88% of subjects and ?60% predicted in 74% of subjects. Patients with a PImax ?60% predicted spent significantly longer time in hospital following HSCT compared with subjects with PImax 60% predicted. Grip strength (n=32) was reduced to ?80% predicted in 75% of subjects and ?60% predicted in 47% of subjects following HSCT. Analysis of paired measurements obtained before and after HSCT in 20 of the 44 subjects (45%) showed significant reduction in both PImax and PEmax between the two measures. Respiratory and skeletal muscle weakness is present in a significant percentage of subjects undergoing pulmonary function testing in the post-HSCT period, and may contribute to pulmonary morbidity in subjects with pulmonary complications of HSCT.Bone Marrow Transplantation (2008) 41, 965�969; doi:10.1038/bmt.2008.15; published online 11 February 2008
ACCESSION #
32566162

 

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