TITLE

Relationship between CD4+ Count and Non-AIDS Diseases in HIV Patients

AUTHOR(S)
Winslow, Dean L.
PUB. DATE
June 2008
SOURCE
Infectious Disease Alert;Jun2008, Vol. 27 Issue 9, p101
SOURCE TYPE
Periodical
DOC. TYPE
Article
ABSTRACT
EXACTLY 1397 ANTIRETROVIRAL (ARV) NAÏVE PATIENTS initiating ARVs, as part of a CPCRA-sponsored clinical trial (FIRST trial), were followed for a median of five years. Patients were randomized to one of three arms (NRTIs + PI, NRTIs + nnRTI, NRTIs + PI + nnRTI). CD4+ lymphocyte count, HIV RNA, along with the incidence of fatal and non-fatal AIDS and non-AIDS diseases (liver, cardiovascular, renal, non-AIDS defined cancers) were assessed during the course of the study. Cox proportional regression models were used to study risk associations. Of those, 227 patients experienced new AIDS-defining events and 80 patients developed non-AIDS events. CD4+ count prior to event was < 200 cells/uL, the AIDS event rate was 13.8 per 100 person-years and non-AIDS event rate was 2.1 per 100 person-years. For those whose latest CD4+ count was 200-350, the event rates were 2.0 and 1.7, respectively. For latest CD4+ > 350, the event rates for both AIDS and non-AIDS events were 0.7 and 0.7, respectively. Looking at latest HIV RNA < 50 copies/mL by univariate analysis, the hazard ratio (HR) for AIDS events was 0.24 and 0.48 for non-AIDS events. By multivariate analysis controlling for CD4+, having HIV RNA < 50 copies/mL, the HR for AIDS and non-AIDS events remained significantly protective at 0.46 and 0.52, respectively.
ACCESSION #
32582413

 

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