Western blot pattern in HIV positive individuals in Namakkal, South India

Sivakumar, M. R.; Kumar, J. Sanath; Viswanath, R.; Thatchinamoorthy, G.; Jacob, Mini; Samuel, N. M.
July 2008
Internet Journal of Infectious Diseases;2008, Vol. 6 Issue 2, p5
Academic Journal
Objective: The objective of this study was to determine the western blot pattern among HIV positive individuals in different stages of HIV infection in Namakkal, South India. Material and methods: After an informed consent, Western Blot test from 40 HIV seropositive patients attending the ART center at Namakkal, were performed using HIVBLOT 2.2, manufactured by Genelabs diagnostics, Singapore, as per the kit instructions. Demographic, clinical and diagnostic data were collected. Results: The age ranged from 22-51 years (mean- 36 years). 47.5% were males and 52.5% were females. The patients were classified according to the WHO stages. Eleven patients were in Stage I, 10 each in Stage II and III and 9 patients were in Stage IV. With the exception of p24, the other GAG proteins, p55, p39 and p17 are not expressed very efficiently in Stage I patients. The expression of gp160, gp41, p66, p31 have all increased by approximately 10-20% in Stage II. In stage III, the ENV proteins gp160 and gp120 have been found in 90% of the cases. There was a 20% decrease in the incidence of p24 protein. Of the nine stage IV samples, 89% conform to the WHO interpretation criteria. Conclusion: Interpretation of the WB band pattern in combination with clinical features may be occasionally useful in predicting the stage of HIV infection. This study suggests that antibodies to gag antigen P17 may be used as a marker for disease progression.


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