Composition and Antibacterial Activity of Essential Oil from Felicia muricata Thunb. Leaves

Ashafa, A. O. T.; Grierson, D. S.; Afolayan, A. J.
July 2008
Journal of Biological Sciences;2008, Vol. 8 Issue 4, p784
Academic Journal
The essential oil was extracted by hydrodistillation. A total of thirty-eight compounds were identified with α-pinene (9.1%) β-pinene (3.5%), myrcene (18.7%), limonene (26.5%), cis-ocimene (2.2%), trans-ocimene (4.8%) and terpineol (3.4%) as the major monoterpenes, while, cis-lachnophyllum ester (16.2%) was the major non-terpenoid polyacetylenic compound. The antibacterial activity of the oil was investigated against 16 bacterial strains using broth microdilution method. The oil inhibited all the test organisms with more pronounced activity on Gram-positive than the Gram-negative bacteria. The Minimum Inhibitory Concentration (MIC) for Gram-positive bacteria range from 0.08-2.50 mg mL-1, whereas, it was 0.08-5.00 mg mL-1 for the Gram-negative bacteria. The ability of the oil from F. muricata to inhibit a range of nosocomial pathogenic bacterial strains at a concentration less than that of streptomycin makes the oil a candidate for possible development of antibiotic chug.


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