Onikomikoz Tanısında Kullanılan YÖntemlerin Karşılaştırılması

Ceren, Eylem; Ekmekci, Tuğba Rezan; Sakız, Damlanur; Köşlü, Adem; Bayraktar, Banu
September 2008
Archives of the Turkish Dermatology & Venerology / Turkderm;2008, Vol. 42 Issue 3, p91
Academic Journal
Background and Design: A potassium hydroxide (KOH) direct microscopic examination, histopathological investigation with periodic acid-Schiff (PAS) stain and fungal culture are common diagnostic methods in the diagnosis of onychomycosis. The purpose of this study was to compare these three methods for the diagnosis of onychomycosis. Material and Method: A total of 100 patients who were suspected clinically of having onychomycosis on their toenails were included in this study. Three diagnostic tests were performed for each patients. In addition to clinical suspicion when one of the diagnostic tests was positive the diagnosis of onychomycosis was made. Accordingly, the sensitivity and the negative predictive value were calculated for each diagnostic test. Results: In 92 (92%) of the patients, at least one of the three diagnostic methods was positive. The sensitivites of these methods were as follows: KOH direct microscopic examination, 92%; histopathological investigation with PAS stain, 80%; and culture, 20%. Their negative predictive values were also 53%, 42%, and 10% respectively. Conclusion: KOH direct microscopic examination is the most sensitive method for the diagnosis of onychomycosis. Its high negative predictive value supports this finding.


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