TITLE

Review of antiretroviral agents for the treatment of HIV infection

AUTHOR(S)
Stanic, Anela; Grana, Julie C.
PUB. DATE
February 2009
SOURCE
Formulary;Feb2009, Vol. 44 Issue 2, p47
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Research into the treatment of HIV infection has resulted in the development of 5 antiretroviral (ARV) drug classes: entry inhibitors, including fusion inhibitors and chemokine coreceptor (CCR) inhibitors; nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs); non-nucleoside reverse transcriptase inhibitors (NNRTIs); integrase inhibitors; and protease inhibitors (PIs). With the approval of the first PIs, the treatment of HIV shifted to highly active ARV therapy (HAART). HAART, which refers to a combination of agents from ≥2 different ARV classes, is a standard approach for treating HIV infection today. The challenge of controlling HIV in patients with resistance to ARVs has contributed to accelerated research into treatments with novel ARV activity. This research has led to the introduction of a CCR5 inhibitor, an integrase inhibitor, and a new NNRTI. This article provides a review of recently approved and investigational agents for the treatment of HIV-1 infection in adult patients, as well as an overview of ARV treatment guidelines. (Formulary. 2009;44;47-54.)
ACCESSION #
36549614

 

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