3-ingredient cocktail makes heart cells from stem cells

Breindl, Anette
May 2009
Medical Device Daily;5/7/2009, Vol. 13 Issue 87, p2
This article discusses a study published in the April 26, 2009 online edition of "Nature" which defined the factors necessary to turn embryonic stem cells into beating heart muscle cells. Both GATA4 and TBX4 are cardiac-specific transcription factors, while BAF60c is a chromatin remodeling factor. Particular focus is given to the different roles of these three factors. Results showed that BAF60c enables GATA4 to access deoxyribonucleic acid (DNA) and facilitate the transcription of genes needed for heart cells to develop.


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