TITLE

Diversity in enoyl-acyl carrier protein reductases

AUTHOR(S)
Massengo-Tiassé, R. P.; Cronana, J. E.
PUB. DATE
May 2009
SOURCE
Cellular & Molecular Life Sciences;May2009, Vol. 66 Issue 9, p1507
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The enoyl-acyl carrier protein reductase (ENR) is the last enzyme in the fatty acid elongation cycle. Unlike most enzymes in this essential pathway, ENR displays an unusual diversity among organisms. The growing interest in ENRs is mainly due to the fact that a variety of both synthetic and natural antibacterial compounds are shown to specifically target their activity. The primary anti-tuberculosis drug, isoniazid, and the broadly used antibacterial compound, triclosan, both target this enzyme. In this review, we discuss the diversity of ENRs, and their inhibitors in the light of current research progress.
ACCESSION #
42527970

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics