TITLE

Synthesis of Nitrogen Mustards of Pyrimdine Derivatives

AUTHOR(S)
Gangawar, T.; Kumari, Sanju; Kumar, Rakesh
PUB. DATE
July 2009
SOURCE
International Journal of Applied Chemistry;2009, Vol. 5 Issue 2, p115
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We have successfully synthesized several derivatives of pyrimidine which can be used as potential anticancer agent. Anticancer study of these compounds will be taken up in next work. The synthesised compounds are listed as 2- hydroxy-4,6-dimethyl pyrimidine (I): 2-hydroxy-4-methyl-6-{4'-[N,N-bis(2- chloroethylyl) amino] styryl} pyrimidine (II), 2-hydroxy-4-methyl-6-{4'- [N,N-bis(2-chloroethylyl) amino] styryl} pyrimidine hydrochloride(III), 2- hydroxy-4-methyl-6-{4'-[N,N-bis(2-chloroethylyl) amino] distyryl} pyrimidine (IV), 2-hydroxy-4-methyl-6-{4'-[N,N-bis(2-chloroethylyl) amino] distyryl} pyrimidine hydrochloride (V), 2-mercapto-4,6-dimethyl pyrimidine (VI), 2-mercapto-4-methyl -6-{4'-[N,N-bis(2-chloroethylyl) amino] styryl} pyrimidine (VII), 2-mercapto-4-methyl -6-{4'-[N,N-bis(2-chloroethylyl) amino] styryl} pyrimidine hydrochloride (VIII), 2-mercapto-4-methyl -6-{4'- [N,N-bis(2-chloroethylyl) amino] distyryl} pyrimidine (IX), 2-mercapto-4- methyl -6-{4'-[N,N-bis(2-chloroethylyl) amino] distyryl} pyrimidine hydrochloride (X). The IR spectra and the elemental analysis of the compounds have been interpreted and the structures have been established.
ACCESSION #
47109076

 

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