Clinical efficacy of first- and second-line treatments for HIV-associated Pneumocystis jirovecii pneumonia: a tri-centre cohort study

Helweg-Larsen, Jannik; Benfield, Thomas; Atzori, Chiara; Miller, Robert F.
December 2009
Journal of Antimicrobial Chemotherapy (JAC);Dec2009, Vol. 64 Issue 6, p1282
Academic Journal
Objectives: First-line therapy for Pneumocystis jirovecii pneumonia (PCP) is trimethoprim/sulfamethoxazole. Few data exist to guide the choice of second-line therapy for patients failing or developing toxicity to first-line therapy.


Related Articles

  • Clindamycin-primaquine versus pentamidine for the second-line treatment of pneumocystis pneumonia. Tark Kim; Sung-Han Kim; Ki-Ho Park; Oh Cho; Heungsup Sung; Mi-Na Kim; Sang-Ho Choi; Jin-Yong Jeong; Jun Woo; Yang Kim; Sang-Oh Lee // Journal of Infection & Chemotherapy (Springer Science & Business;Oct2009, Vol. 15 Issue 5, p343 

    Abstract  There are limited data on the efficacy of alternative regimens for treating patients with pneumocystis pneumonia (PCP). We compared the efficacy of clindamycin-primaquine (C-P) with that of pentamidine as a secondline treatment for PCP. Among 91 patients receiving...

  • Trimethoprim-sulfamethoxazole or pentamidine for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective randomized trial. Wharton, J. Marcus; Coleman, Diana Lewis; Wofsy, Constance B.; Luce, John M.; Blumenfeld, Walter; Hadley, W. Keith; Ingram-Drake, Leslie; Volberding, Paul A.; Hopewell, Philip C.; Wharton, J M; Coleman, D L; Wofsy, C B; Luce, J M; Blumenfeld, W; Hadley, W K; Ingram-Drake, L; Volberding, P A; Hopewell, P C // Annals of Internal Medicine;Jul86, Vol. 105 Issue 1, p37 

    Forty patients with the acquired immunodeficiency syndrome (AIDS) and their first episodes of Pneumocystis carinii pneumonia were assigned at random to receive either trimethoprim-sulfamethoxazole or pentamidine isethionate. The two groups did not differ significantly in the severity of...

  • Dapsone-Trimethoprim for Pneumonia in the Acquired Immunodeficiency Syndrome. Leoung, Clifford S.; Mills, John; Hopewell, Philip C.; Hughes, Walter; Wofsy, Constance // Annals of Internal Medicine;Jul86, Vol. 105 Issue 1, p45 

    Presents a study that examined the efficacy of dapsone plus trimethoprim for the treatment of patients with AIDS and a first episode of Pneumocystis carinii pneumonia. Methodology; Characteristics of patients with AIDS and Pneumocystis carinii pneumonia treated with dapsone-trimethoprim;...

  • Clindamycin/tacrolimus interaction.  // Reactions Weekly;10/2/2010, Issue 1321, p14 

    The article describes the case of a woman who experienced decreased serum tacrolimus concentrations after starting clindamycin to treat Pneumocystis carinii (P. jirovecii) pneumonia.

  • Sirolimus.  // Reactions Weekly;6/30/2007, Issue 1158, p24 

    The article describes the case of a 55-year-old man who developed alveolar hemorrhage during immunosuppression with sirolimus following a heart transplant. It references a study by W. I. Khalife et al, published in the June 2007 issue of the "Journal of Heart and Lung Transplantation." The man...

  • Cost and Benefit of Secondary Prophylaxis for Pneumocystis carinii Pneumonia. Castellano, Abel R.; Nettleman, Mary D. // JAMA: Journal of the American Medical Association;8/14/91, Vol. 266 Issue 6, p820 

    Presents a study that determined the relative cost and benefit of aerosolized pentamidine and the combination product of sulfamethoxazole and trimethoprim sulfate as secondary prophylaxis for Pneumocystis carinii pneumonia. Methods used in formulating a cost-benefit analysis of patients ...

  • Trimethoprim-sulfamethoxazole compared with pentamidine for treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective, noncrossover study. Sattler, Fred R.; Cowan, Robert; Nielsen, Donald M.; Ruskin, Joel; Sattler, F R; Cowan, R; Nielsen, D M; Ruskin, J // Annals of Internal Medicine;8/15/88, Vol. 109 Issue 4, p280 

    Study Objective: To ascertain the efficacy and toxicity of trimethoprim-sulfamethoxazole or pentamidine when either is given alone during the entire treatment period for Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS).Design:...

  • Cotrimoxazole.  // Reactions Weekly;1/21/2017, Vol. 1635 Issue 1, p95 

    An abstract of the article "Successful treatment of severe Pneumocystis pneumonia in an immunosuppressed patient using caspofungin combined with clindamycin: A case report and literature review" by H. Li and others is presented.

  • Pneumocystis carinii pneumonia.  // Modern Medicine;Aug95, Vol. 63 Issue 8, p26 

    Reports on the US Food and Drug Administration's approval on the marketing of a suspension form of atovaquone in the treatment of pneumocystis carinii pneumonia. Advantages and convenience; Dosage.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics