TITLE

Antioxidant activities of dithiol alpha-lipoic acid

AUTHOR(S)
Islam, M. T.
PUB. DATE
June 2009
SOURCE
Bangladesh Journal of Medical Science;Jun2009, Vol. 8 Issue 3, p6
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Alpha-lipoic acid, a dithiol compound derived from octanoic acid, which acts as a coenzyme for several redox reactions in almost all the tissue of the body. It retains its protective functions in both oxidized and reduced forms. Alpha-lipoic acid reduces oxidative stress by redox generation of other antioxidants such as vitamin C, E and increasing the intracellular glutathione. Exogenous alpha-lipoic acid has been shown to increase ATP production due to its role in the oxidation of pyruvate and alpha-ketoglutarate in the mitochondria. Alpha-lipoic acid administration has been shown to be effective in preventing pathology in various experimental models in which reactive oxygen species have been implicated.
ACCESSION #
47565252

 

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