TITLE

Evidence for a "Founder Effect" among HIV-infected injection drug users (IDUs) in Pakistan

AUTHOR(S)
Rai, Mohammad A.; Nerurkar, Vivek R.; Khoja, Suhail; Khan, Saeed; Yanagihara, Richard; Rehman, Arish; Kazmi, Shahana U.; Ali, Syed H.
PUB. DATE
January 2010
SOURCE
BMC Infectious Diseases;2010, Vol. 10 Issue 1, Special section p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: We have previously reported a HIV-1 subtype A infection in a community of injection drug users (IDUs) in Karachi, Pakistan. We now show that this infection among the IDUs may have originated from a single source. Methods: Phylogenetic analysis was performed of partial gag sequences, generated using PCR, from 26 HIVpositive IDU samples. Results: Our results showed formation of a tight monophyletic group with an intra-sequence identity of < 98% indicating a "founder effect". Our data indicate that the HIV-1 epidemic in this community of IDUs may have been transmitted by an HIV positive overseas contract worker who admitted to having contact with commercial sex workers during stay abroad. Conclusion: Specific measures need to implemented to control transmission of HIV infection in Pakistan through infected migrant workers.
ACCESSION #
48612492

 

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