The Virologic and Immunologic Effects of Cyclosporine as an Adjunct to Antiretroviral Therapy in Patients Treated during Acute and Early HIV-1 Infection

Markowitz, Martin; Vaida, Florin; Hare, C. Bradley; Boden, Daniel; Mohri, Hiroshi; Hecht, Frederick M.; Kalayjian, Robert C.; Conrad, Ann; Mildvan, Donna; Aberg, Judith; Hogan, Christine; Kilby, J. Michael; Balfour Jr., Henry H.; Schafer, Kim; Richman, Douglas; Little, Susan
May 2010
Journal of Infectious Diseases;5/1/2010, Vol. 201 Issue 9, p1298
Academic Journal
Acute human immunodeficiency virus type 1 (HIV-1) infection is characterized by high levels of immune activation. Immunomodulation with cyclosporine combined with antiretroviral therapy (ART) in the setting of acute and early HIV-1 infection has been reported to result in enhanced immune reconstitution. Fifty-four individuals with acute and early infection were randomized to receive ART with 4 weeks of cyclosporine versus ART alone. In 48 subjects who completed the study, there were no significant differences between treatment arms in levels of proviral DNA or CD4+ T cell counts. Adjunctive therapy with cyclosporine in this setting does not provide apparent virologic or immunologic benefit.


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