Microbial Translocation and HIV Infection

Winslow, Dean L.
June 2010
Infectious Disease Alert;Jun2010, Vol. 29 Issue 9, p97
Twenty-one patients with HIV-1/AIDs, seven patients with HIV-2/AIDS, 43 patients with HIV-1 chronic infection, and 66 patients with HIV-2 chronic infection in Guinea-Bissau were studied along with 66 HIV-negative policemen. LPS was measured by limulus amebocyte lysate assay, and IL-12 and IFN-alpha were measured in whole blood following mitogen and toll-like receptor (TLR) stimulation. Elevated microbial translocation (as assessed by LPS levels) was correlated with the presence of AIDS, lower CD4+ lymphocyte count, and higher viral load, but was independent of type of HIV infection (HIV-1 vs. HIV-2). In addition, defective mitogen and innate immune responsiveness was correlated with LPS level.


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