Adaptive design: Points to consider

July 2010
IRB Advisor;Jul2010, Vol. 10 Issue 7, p80
The article discusses the aspects to be considered in the use of adaptive design. Several issues concerning the Institutional Review Board (IRB) which can be affected by adaptive design are cited, which include informed consent of research participants and the misconceptions on the difference between research and treatment when changing interventions. Noted is the use of computer-generated trial simulation as a new tool that could help the IRB in the review of adaptive design.


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