Zoster Incidence in Human Immunodeficiency Virus-Infected Hemophiliacs and Homosexual Men, 1984-1997

Engels, Eric A.; Rosenberg, Philip S.
December 1999
Journal of Infectious Diseases;12/1/99, Vol. 180 Issue 6, p1784
Academic Journal
Zoster is an important clinical problem for human immunodeficiency virus type 1 (HIV)-infected patients. Risk factors for zoster and trends in incidence in HIV-infected hemophiliacs and homosexual men (n = 1218) were examined. From 1984 to 1997, 174 zoster cases were identified (average yearly incidence, 2.5%). Prior zoster episodes were associated with increased risk for a subsequent episode (relative risk [RR], 4.30; 95% confidence interval [CI], 3.11-5.95). Among hemophiliacs, children and adolescents had the highest zoster risk, and zoster risk declined with age (RR, 0.80 per decade; 95% CI, 0.68-0.93). These findings suggest that HIV-infected persons do not produce or maintain adequate booster responses after varicella zoster virus exposure. Zoster risk was relatively constant when CD4 cell counts >200 cells/mm[sup3] but increased steeply below this level. During the 14 years of follow-up, zoster incidence declined 9% per year. This trend occurred despite decreasing CD4 cell counts and was unexplained by zidovudine or acyclovir use.


Related Articles

  • Incidence of Dilated Cardiomyopathy and Detection of HIV in Myocardial Cells of HIV-Positive Patients. Barbaro, Giuseppe; Di Lorenzo, Gabriella; Grisorio, Benvenuto; Barbarini, Giorgio // New England Journal of Medicine;10/15/98, Vol. 339 Issue 16, p1093 

    Background: Human immunodeficiency virus (HIV) infection is increasingly recognized as an important cause of dilated cardiomyopathy. However, the pathogenesis of the heart-muscle disease in the acquired immunodeficiency syndrome is unclear. Methods: We performed a prospective, long-term clinical...

  • A challenge to the concept of accelerated aging with HIV.  // Research Initiative/Treatment Action!;Spring2010, Vol. 15 Issue 1, p19 

    An interview with Carl Grunfeld, professor of medicine at University of California in San Francisco, California, is presented. When asked about non-AIDS risks for aging people undergoing antiretroviral therapy, Gurnfeld notes that diseases marked by inflammation or immune abnormalities are...

  • Risk of Onset of Hematological Malignancies in Patients Infected with the Hepatitis B Virus: Results from a Large-Scale Retrospective Cohort Study in China. Li, Xiaoyang; Zheng, Yu; Zhu, Hongming; Lin, Xiaojing; Zhang, Yunxiang; Zhao, Yubing; Hu, Jiong; Li, Junmin // Acta Haematologica;Jun2017, Vol. 137 Issue 4, p209 

    The hepatitis B virus (HBV) is a major global issue, because an increased risk of hepatocellular carcinoma among patients infected with HBV is well established. Recently, it has been suggested that HBV is associated with other human cancers. However, the association between HBV and the risk of...

  • Kidney disease with HIV: not rare, not rarely fatal. Mascolini, Mark // Research Initiative/Treatment Action!;Fall2014, Vol. 19 Issue 2, p5 

    US clinicians described HIV-associated nephropathy (HIVAN) in the early days of the epidemic. Although combination antiretroviral therapy (cART) made HIVAN an increasingly rare complication, chronic kidney disease (CKD) persists in HIV populations, affecting 5% to 25% of HIV groups in the United...

  • Herpes zoster in HIV-1-infected patients in the era of highly active antiretroviral therapy: a prospective observational study. Chien-Ching Hung; Chin-Fu Hsiao; Jiun-Ling Wang; Mao-Yuan Chen; Szu-Min Hsieh; Wang-Hwei Sheng; Shan-Chwen Chang // International Journal of STD & AIDS;Oct2005, Vol. 16 Issue 10, p673 

    Between June 1994 and May 2003, 93 of 716 (13.0%) HIV-infected patients with a median baseline cell differentiation CD4+ count of 61 × 106 cells/L (range, 1–1206 × 106 cells/L) developed 103 episodes of herpes zoster [HZ], with an incidence of 5.67 per 100 person-years (PY). The...

  • Classic and HIV-specific risk factors for kidney disease. Mascolini, Mark // Research Initiative/Treatment Action!;Fall2014, Vol. 19 Issue 2, p26 

    Several variables that heighten kidney disease risk in the general population are highly prevalent in HIV populations, including diabetes, hypertension, HCV infection, and smoking. Blacks run a higher risk of kidney disease than whites. As people with HIV live longer thanks to antiretroviral...

  • Risk of Cardiovascular Events Associated With Current Exposure to HIV Antiretroviral Therapies in a US Veteran Population. Desai, Manisha; Joyce, Vilija; Bendavid, Eran; Olshen, Richard A.; Hlatky, Mark; Chow, Adam; Holodniy, Mark; Barnett, Paul; Owens, Douglas K. // Clinical Infectious Diseases;8/1/2015, Vol. 61 Issue 3, p445 

    Background. To characterize the association of antiretroviral drug combinations on risk of cardiovascular events. Methods. Certain antiretroviral medications for human immunodeficiency virus (HIV) have been implicated in increasing risk of cardiovascular disease. However, antiretroviral drugs...

  • Usefulness of calcaneal quantitative ultrasound stiffness for the evaluation of bone health in HIV- 1-infected subjects: comparison with dual X-ray absorptiometry. Fantauzzi, Alessandra; Floridia, Marco; Ceci, Fabrizio; Cacciatore, Francesco; Vullo, Vincenzo; Mezzaroma, Ivano // HIV/AIDS - Research & Palliative Care;May2016, Vol. 8, p109 

    Objectives: With the development of effective treatments and the resulting increase in life expectancy, bone mineral density (BMD) alteration has emerged as an important comorbidity in human immunodeficiency virus type-1 (HIV-1)-infected individuals. The potential contributors to the...

  • Untitled. Smith, Jeanette M. // JAMA: Journal of the American Medical Association;4/6/94, Vol. 271 Issue 13, p966f 

    Presents an abstract of the article `Prevalence of Rheumatic Manifestations in Human Immunodeficiency Virus Infection,' by Olivier Rogeaux and others, which was lifted from an internal medicine journal. Percentage of Raynaud's phenomenon prevalence; Statistical link between different rheumatic...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics