TITLE

Zoster Incidence in Human Immunodeficiency Virus-Infected Hemophiliacs and Homosexual Men, 1984-1997

AUTHOR(S)
Engels, Eric A.; Rosenberg, Philip S.
PUB. DATE
December 1999
SOURCE
Journal of Infectious Diseases;12/1/99, Vol. 180 Issue 6, p1784
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Zoster is an important clinical problem for human immunodeficiency virus type 1 (HIV)-infected patients. Risk factors for zoster and trends in incidence in HIV-infected hemophiliacs and homosexual men (n = 1218) were examined. From 1984 to 1997, 174 zoster cases were identified (average yearly incidence, 2.5%). Prior zoster episodes were associated with increased risk for a subsequent episode (relative risk [RR], 4.30; 95% confidence interval [CI], 3.11-5.95). Among hemophiliacs, children and adolescents had the highest zoster risk, and zoster risk declined with age (RR, 0.80 per decade; 95% CI, 0.68-0.93). These findings suggest that HIV-infected persons do not produce or maintain adequate booster responses after varicella zoster virus exposure. Zoster risk was relatively constant when CD4 cell counts >200 cells/mm[sup3] but increased steeply below this level. During the 14 years of follow-up, zoster incidence declined 9% per year. This trend occurred despite decreasing CD4 cell counts and was unexplained by zidovudine or acyclovir use.
ACCESSION #
5145577

 

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