TITLE

Liver Histology and HBV DNA Levels in Chronically HBV Infected Patients with Persistently Normal Alanine Aminotransferase

AUTHOR(S)
Montazeri, Ghodrate; Rahban, Maryam; Mohamadnejad, Mehdi; Zamani, Farhad; Hooshyar, Afshin; Fazlolahi, Atoosa; Abedian, Shifteh; Ghoujeghi, Farhad; Estakhri, Arezoo; Montazeri, Farhad; Razjoyan, Hadi; Mamarabadi, Mansoureh; Alimohamadi, Meysam; Tavangar, Seyed Mohamad; Malekzadeh, Reza
PUB. DATE
May 2010
SOURCE
Archives of Iranian Medicine (AIM);May2010, Vol. 13 Issue 3, p193
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Data on histological activity and HBV DNA levels in patients with chronic HBV infection and persistently normal alanine aminotransferase levels are sparse. We aimed to investigate the histological activity and HBV DNA levels in these patients. Methods: There were 132 patients with HBeAg negative chronic HBV infection and persistently normal alanine aminotransferase levels that were included prospectively. Data were dichotomized according to the median levels. Associations of histology with HBV DNA and other variables were assessed. Results: A total of 80 patients were male. The median age was 36 years. The median baseline HBV DNA was 2.9Log10 IU/mL. There were 50 cases (38%) with a total score ⩾5, 53 cases (40.2%) had grade ⩾4 and 40 cases (30.3%) had stage ⩾2. A baseline HBV DNA <2000 IU/mL was seen in 24 cases (48 %) of those with total score ⩾5, 28 cases (53%) of those with grade ⩾4 and 9 cases (22.5%) with stage ⩾2. Multivariate analysis of baseline HBV DNA above the median level significantly predicted the total score, grade and stage with an adjusted odds ratio of 5.43, 3.47, and 4.23, respectively when compared to below median values. A second liver biopsy was performed in 61 patients. The median time interval between the two biopsies was 40 months. Total scores of 23 cases (38%) progressed by ⩾2 scores and the HBV DNA of 18 cases (22.5 %) increased by ⩾1 Log10 IU when compared to baseline values. Conclusions: HBeAg negative chronic HBV infection with persistently normal alanine aminotransferase is not a silent disease. Active liver disease may be seen in such patients with viral loads less than 2000 IU/mL.
ACCESSION #
52046075

 

Related Articles

  • Evaluation of Liver Biopsy in Egyptian HBeAg-Negative Chronic Hepatitis B Patients at Initial Presentation: Implications for Therapy. El-Zayadi, Abdel-Rahman; Badran, Hanaa Mostafa; Saied, Ahmed; Shawky, Sherine; Attia, Mohy El-Deen; Zalata, Khaled // American Journal of Gastroenterology (Springer Nature);Apr2009, Vol. 104 Issue 4, p906 

    OBJECTIVES:A subgroup of HBeAg-negative chronic hepatitis B (CHB) patients with alanine aminotransferase (ALT) and/or hepatitis B virus (HBV)-DNA levels below the cutoff values of international guidelines may have significant liver disease and miss the opportunity for early treatment....

  • Prediction of liver histological lesions with biochemical markers in chronic hepatitis B patients in Iran. Alavian, Seyed Moayed; Alavian, Seyed Hoda; Ashayeri, Neda; Babaei, Marziyeh; Daneshbodi, Maryam; Hajibeigi, Bashir // Gastroenterology & Hepatology from Bed to Bench;Apr2010, Vol. 3 Issue 2, p71 

    Aim: In the current study, we aimed at identifying independent laboratory parameter to predict liver damage. Background: Although liver biopsy is frequently recommended in assessing disease severity and selecting antiviral treatment candidates, it has several limitations. Patients and methods: A...

  • Expression of CD39 on FoxP3 T cells correlates with progression of HBV infection.  // BMC Immunology;2012, Vol. 13 Issue 1, p17 

    The article presents a study conducted by the authors related to association of CD39+ T cells, tregs with hepatitis B virus (HBV) infection. Analysis of HBV patients was conducted to assess association of the treg with HBV copy number and the liver injury marker alanine aminotransferase (ALT)....

  • Laparoscopic findings of reddish markings predict hepatocellular carcinoma in patients with hepatitis B virus-related liver disease. Shoji, Bon; Ikeda, Fusao; Fujioka, Shin-ichi; Kobashi, Haruhiko; Yasunaka, Tetsuya; Miyake, Yasuhiro; Shiraha, Hidenori; Takaki, Akinobu; Nouso, Kazuhiro; Iwasaki, Yoshiaki; Yamamoto, Kazuhide // Journal of Gastroenterology;Nov2010, Vol. 45 Issue 11, p1172 

    Background: For patients with chronic hepatitis due to hepatitis B virus (HBV), factors predicting hepatocellular carcinoma (HCC) other than high levels of HBV-DNA and alanine aminotransferase (ALT) are needed to prevent HCC development, as many patients with chronic HBV infection fulfill these...

  • Clinical outcomes of low-dose leflunomide for rheumatoid arthritis complicated with Hepatitis B virus carriage and safety observation. Ming-Hua Xu; Meng Chen; Yun Cai; Yan-Hui Jia // Pakistan Journal of Medical Sciences;Mar/Apr2015, Vol. 31 Issue 2, p320 

    Objective: To study the clinical outcomes of low-dose leflunomide for rheumatoid arthritis (RA) complicated with hepatitis B virus (HBV) carriage and to observe the safety. Methods: A total of 115 RA patients were divided into three groups according to the state of HBV. They were all given...

  • Adefovir dipivoxil monotherapy is a sufficiently effective treatment modality for Japanese patients with lamivudine-resistant chronic hepatitis B. Sato, Ken; Takagi, Hitoshi; Kakizaki, Satoru; Sohara, Naondo; Mori, Masatomo // Journal of Gastroenterology;Mar2006, Vol. 41 Issue 3, p283 

    The article presents a study to evaluate the efficacy of adefovir dipivoxil monotherapy for Japanese patients with lamivudine-resistant chronic hepatitis B. The study found that the alanine aminotransferase level in all the patients under observation decreased and normalized in 67 percent...

  • Mild-to-Moderate Elevation of Alanine Aminotransferase Increases Liver Stiffness Measurement by Transient Elastography in Patients With Chronic Hepatitis B. James Fung; Ching-Lung Lai; Charles Cheng; Ringo Wu; Danny Ka-Ho Wong; Man-Fung Yuen // American Journal of Gastroenterology;Mar2011, Vol. 106 Issue 3, p492 

    OBJECTIVES:Liver stiffness measurement has been shown to be increased in severe acute flares of hepatitis. Whether lesser degree of hepatitis can also increase liver stiffness is not known. The present study aimed to investigate the effect of mild-to-moderate elevations of alanine...

  • Hepatitis B-More Treatments, More Testing, Not Enough Data. Fox, Rena K. // JGIM: Journal of General Internal Medicine;Mar2011, Vol. 26 Issue 3, p232 

    The article focuses on two papers highlighting issues critical to hepatitis B virus (HBV) management for general internal medicine. It says that the study by T. Juday and colleagues raises the question on the cost effectiveness of annual laboratory monitoring of alanine aminotransferase (ALT)...

  • G-to-A Hypermutation in Hepatitis B Virus (HBV) and Clinical Course of Patients with Chronic HBV Infection. Noguchi, Chiemi; Imamura, Michio; Tsuge, Masataka; Hiraga, Nobuhiko; Mori, Nami; Miki, Daiki; Kimura, Takashi; Takahashi, Shoichi; Fujimoto, Yoshifumi; Ochi, Hidenori; Abe, Hiromi; Maekawa, Toshiro; Tateno, Chise; Yoshizato, Katsutoshi; Chayama, Kazuaki // Journal of Infectious Diseases;6/1/2009, Vol. 199 Issue 11, p1599 

    Background. The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like family of cytidine deaminases induce G-to-A hypermutation in hepatitis B virus (HBV) genomes and play a role in innate antiviral immunity. The clinical relevance of this protein family is unknown. Methods....

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics